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    IL-1alpha in acetaminophen toxicity: a sterile danger signal

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    Authors
    Iracheta-Vellve, Arvin
    Szabo, Gyongyi
    UMass Chan Affiliations
    UMass Metabolic Network
    Department of Medicine, Division of Gastroenterology
    Graduate School of Biomedical Sciences, Translational Science Program
    Document Type
    Letter to the Editor
    Publication Date
    2017-11-20
    Keywords
    Biochemistry
    Cell Biology
    Cellular and Molecular Physiology
    Immunopathology
    Molecular Biology
    
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    Link to Full Text
    https://doi.org/10.1038/cmi.2017.108
    Abstract
    Much controversy surrounds the pathogenesis of acetaminophen-induced inflammation. Acetaminophen (APAP) is a well-studied xenobiotic that in high doses results in a deadly, yet preventable, form of liver failure. Although its effects are sudden and often irreversible, its mechanism is far from simple. In fact, at first glance, recent studies seem to refute each other. The field has been grappling with seemingly contradictory results driven mainly by often-generalized assumptions and different experimental systems. As always, the devil—or in this case, liver failure—is in the details. In this paper, Tang and colleagues identified macrophage-derived interleukin (IL)-1α as a mediator of sterile inflammation in a mouse model of APAP hepatotoxicity. IL-1α is an alarmin that unlike IL-1β, is constitutively expressed in many cells as a precursor. IL-1α precursor (pre-IL-1α) is active as a damage-associated molecular pattern (DAMP). After enzymatic cleavage, mature IL-1α can signal a more potent pro-inflammatory message.
    Source
    Cell Mol Immunol. 2017 Nov 20. pii: cmi2017108. doi: 10.1038/cmi.2017.108. Link to article on publisher's site
    DOI
    10.1038/cmi.2017.108
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/36621
    PubMed ID
    29151582
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1038/cmi.2017.108
    Scopus Count
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    Morningside Graduate School of Biomedical Sciences Scholarly Publications
    UMass Chan Faculty and Researcher Publications

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