CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells
Anderson, Nicole M.
Tang, Kevin Charles
Roderick, Justine E.
Kelliher, Michelle A.
Seldin, David C.
UMass Chan AffiliationsSenior Scholars Program
School of Medicine
UMass Metabolic Network
Department of Molecular, Cell and Cancer Biology
Document TypeLetter to the Editor
MetadataShow full item record
AbstractHere we show that CK2 inhibition by CX-4945 destabilizes NOTCH1 and synergizes with JQ1 to induce apoptosis in human T-ALL cells, implicating an alternative strategy to target NOTCH1 signaling in refractory/relapsed T-ALL.
Haematologica. 2017 Jan;102(1):e17-e21. doi: 10.3324/haematol.2016.154013. Epub 2016 Oct 6. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/36661
Kevin Charles Tang participated in this study as a medical student as part of the Senior Scholars research program at the University of Massachusetts Medical School.