CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells
Authors
Lian, HaiweiLi, Dun
Zhou, Yun
Landesman-Bollag, Esther
Zhang, Guanglan
Anderson, Nicole M.
Tang, Kevin Charles
Roderick, Justine E.
Kelliher, Michelle A.
Seldin, David C.
Fu, Hui
Feng, Hui
UMass Chan Affiliations
Senior Scholars ProgramSchool of Medicine
UMass Metabolic Network
Department of Molecular, Cell and Cancer Biology
Document Type
Letter to the EditorPublication Date
2017-01-01
Metadata
Show full item recordAbstract
Here we show that CK2 inhibition by CX-4945 destabilizes NOTCH1 and synergizes with JQ1 to induce apoptosis in human T-ALL cells, implicating an alternative strategy to target NOTCH1 signaling in refractory/relapsed T-ALL.Source
Haematologica. 2017 Jan;102(1):e17-e21. doi: 10.3324/haematol.2016.154013. Epub 2016 Oct 6. Link to article on publisher's site
DOI
10.3324/haematol.2016.154013Permanent Link to this Item
http://hdl.handle.net/20.500.14038/36661PubMed ID
27758824Notes
Kevin Charles Tang participated in this study as a medical student as part of the Senior Scholars research program at the University of Massachusetts Medical School.
Related Resources
Rights
Copyright © Ferrata Storti Foundation. Haematologica is an open access journal. Publisher pdf posted as allowed by author guidelines at http://www.haematologica.org/information-for-authors.ae974a485f413a2113503eed53cd6c53
10.3324/haematol.2016.154013