CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells
UMass Chan Affiliations
Senior Scholars ProgramSchool of Medicine
UMass Metabolic Network
Department of Molecular, Cell and Cancer Biology
Document Type
Letter to the EditorPublication Date
2017-01-01Metadata
Show full item recordAbstract
Here we show that CK2 inhibition by CX-4945 destabilizes NOTCH1 and synergizes with JQ1 to induce apoptosis in human T-ALL cells, implicating an alternative strategy to target NOTCH1 signaling in refractory/relapsed T-ALL.Source
Haematologica. 2017 Jan;102(1):e17-e21. doi: 10.3324/haematol.2016.154013. Epub 2016 Oct 6. Link to article on publisher's site
DOI
10.3324/haematol.2016.154013Permanent Link to this Item
http://hdl.handle.net/20.500.14038/36661PubMed ID
27758824Notes
Kevin Charles Tang participated in this study as a medical student as part of the Senior Scholars research program at the University of Massachusetts Medical School.