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dc.contributor.authorLian, Haiwei
dc.contributor.authorLi, Dun
dc.contributor.authorZhou, Yun
dc.contributor.authorLandesman-Bollag, Esther
dc.contributor.authorZhang, Guanglan
dc.contributor.authorAnderson, Nicole M.
dc.contributor.authorTang, Kevin Charles
dc.contributor.authorRoderick, Justine E.
dc.contributor.authorKelliher, Michelle A.
dc.contributor.authorSeldin, David C.
dc.contributor.authorFu, Hui
dc.contributor.authorFeng, Hui
dc.date2022-08-11T08:09:20.000
dc.date.accessioned2022-08-23T16:26:54Z
dc.date.available2022-08-23T16:26:54Z
dc.date.issued2017-01-01
dc.date.submitted2017-02-16
dc.identifier.citation<p>Haematologica. 2017 Jan;102(1):e17-e21. doi: 10.3324/haematol.2016.154013. Epub 2016 Oct 6. <a href="https://doi.org/10.3324/haematol.2016.154013">Link to article on publisher's site</a></p>
dc.identifier.issn0390-6078 (Linking)
dc.identifier.doi10.3324/haematol.2016.154013
dc.identifier.pmid27758824
dc.identifier.urihttp://hdl.handle.net/20.500.14038/36661
dc.description<p>Kevin Charles Tang participated in this study as a medical student as part of the Senior Scholars research program at the University of Massachusetts Medical School.</p>
dc.description.abstractHere we show that CK2 inhibition by CX-4945 destabilizes NOTCH1 and synergizes with JQ1 to induce apoptosis in human T-ALL cells, implicating an alternative strategy to target NOTCH1 signaling in refractory/relapsed T-ALL.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=27758824&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210253/
dc.rightsCopyright © Ferrata Storti Foundation. Haematologica is an open access journal. Publisher pdf posted as allowed by author guidelines at http://www.haematologica.org/information-for-authors.
dc.subjectBiochemistry
dc.subjectCancer Biology
dc.subjectCell Biology
dc.subjectCellular and Molecular Physiology
dc.subjectMolecular Biology
dc.titleCK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells
dc.typeLetter to the Editor
dc.source.journaltitleHaematologica
dc.source.volume102
dc.source.issue1
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1002&amp;context=metnet_pubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/metnet_pubs/3
dc.identifier.contextkey9698854
refterms.dateFOA2022-08-23T16:26:54Z
html.description.abstract<p>Here we show that CK2 inhibition by CX-4945 destabilizes NOTCH1 and synergizes with JQ1 to induce apoptosis in human T-ALL cells, implicating an alternative strategy to target NOTCH1 signaling in refractory/relapsed T-ALL.</p>
dc.identifier.submissionpathmetnet_pubs/3
dc.contributor.departmentSenior Scholars Program
dc.contributor.departmentSchool of Medicine
dc.contributor.departmentUMass Metabolic Network
dc.contributor.departmentDepartment of Molecular, Cell and Cancer Biology
dc.source.pagese17-e21


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