CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells
dc.contributor.author | Lian, Haiwei | |
dc.contributor.author | Li, Dun | |
dc.contributor.author | Zhou, Yun | |
dc.contributor.author | Landesman-Bollag, Esther | |
dc.contributor.author | Zhang, Guanglan | |
dc.contributor.author | Anderson, Nicole M. | |
dc.contributor.author | Tang, Kevin Charles | |
dc.contributor.author | Roderick, Justine E. | |
dc.contributor.author | Kelliher, Michelle A. | |
dc.contributor.author | Seldin, David C. | |
dc.contributor.author | Fu, Hui | |
dc.contributor.author | Feng, Hui | |
dc.date | 2022-08-11T08:09:20.000 | |
dc.date.accessioned | 2022-08-23T16:26:54Z | |
dc.date.available | 2022-08-23T16:26:54Z | |
dc.date.issued | 2017-01-01 | |
dc.date.submitted | 2017-02-16 | |
dc.identifier.citation | <p>Haematologica. 2017 Jan;102(1):e17-e21. doi: 10.3324/haematol.2016.154013. Epub 2016 Oct 6. <a href="https://doi.org/10.3324/haematol.2016.154013">Link to article on publisher's site</a></p> | |
dc.identifier.issn | 0390-6078 (Linking) | |
dc.identifier.doi | 10.3324/haematol.2016.154013 | |
dc.identifier.pmid | 27758824 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/36661 | |
dc.description | <p>Kevin Charles Tang participated in this study as a medical student as part of the Senior Scholars research program at the University of Massachusetts Medical School.</p> | |
dc.description.abstract | Here we show that CK2 inhibition by CX-4945 destabilizes NOTCH1 and synergizes with JQ1 to induce apoptosis in human T-ALL cells, implicating an alternative strategy to target NOTCH1 signaling in refractory/relapsed T-ALL. | |
dc.language.iso | en_US | |
dc.relation | <p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=27758824&dopt=Abstract">Link to Article in PubMed</a></p> | |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210253/ | |
dc.rights | Copyright © Ferrata Storti Foundation. Haematologica is an open access journal. Publisher pdf posted as allowed by author guidelines at http://www.haematologica.org/information-for-authors. | |
dc.subject | Biochemistry | |
dc.subject | Cancer Biology | |
dc.subject | Cell Biology | |
dc.subject | Cellular and Molecular Physiology | |
dc.subject | Molecular Biology | |
dc.title | CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells | |
dc.type | Letter to the Editor | |
dc.source.journaltitle | Haematologica | |
dc.source.volume | 102 | |
dc.source.issue | 1 | |
dc.identifier.legacyfulltext | https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1002&context=metnet_pubs&unstamped=1 | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/metnet_pubs/3 | |
dc.identifier.contextkey | 9698854 | |
refterms.dateFOA | 2022-08-23T16:26:54Z | |
html.description.abstract | <p>Here we show that CK2 inhibition by CX-4945 destabilizes NOTCH1 and synergizes with JQ1 to induce apoptosis in human T-ALL cells, implicating an alternative strategy to target NOTCH1 signaling in refractory/relapsed T-ALL.</p> | |
dc.identifier.submissionpath | metnet_pubs/3 | |
dc.contributor.department | Senior Scholars Program | |
dc.contributor.department | School of Medicine | |
dc.contributor.department | UMass Metabolic Network | |
dc.contributor.department | Department of Molecular, Cell and Cancer Biology | |
dc.source.pages | e17-e21 |