Intergenerational Transfer of Epigenetic Information in Sperm
| dc.contributor.author | Rando, Oliver J. | |
| dc.date | 2022-08-11T08:09:20.000 | |
| dc.date.accessioned | 2022-08-23T16:26:58Z | |
| dc.date.available | 2022-08-23T16:26:58Z | |
| dc.date.issued | 2016-05-02 | |
| dc.date.submitted | 2017-04-20 | |
| dc.identifier.citation | Cold Spring Harb Perspect Med. 2016 May 2;6(5). pii: a022988. 10.1101/cshperspect.a022988. <a href="https://doi.org/10.1101/cshperspect.a022988">Link to article on publisher's site</a> | |
| dc.identifier.issn | 2157-1422 (Linking) | |
| dc.identifier.doi | 10.1101/cshperspect.a022988 | |
| dc.identifier.pmid | 26801897 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/36675 | |
| dc.description.abstract | The inheritance of information beyond DNA sequence, known as epigenetic inheritance, has been implicated in a multitude of biological processes from control of plant flowering time to cancer in humans. In addition to epigenetic inheritance that occurs in dividing cells of a multicellular organism, it is also increasingly clear that at least some epigenetic information is transmitted via the gametes in a multitude of organisms, including mammals. Here, I review the evidence for epigenetic information carriers in mammalian sperm, and explore the emerging field of intergenerational transfer of environmental information. | |
| dc.language.iso | en_US | |
| dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=26801897&dopt=Abstract">Link to Article in PubMed</a> | |
| dc.relation.url | https://doi.org/10.1101/cshperspect.a022988 | |
| dc.subject | Cell Biology | |
| dc.subject | Cellular and Molecular Physiology | |
| dc.subject | Genetics | |
| dc.subject | Molecular Genetics | |
| dc.title | Intergenerational Transfer of Epigenetic Information in Sperm | |
| dc.type | Journal Article | |
| dc.source.journaltitle | Cold Spring Harbor perspectives in medicine | |
| dc.source.volume | 6 | |
| dc.source.issue | 5 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/metnet_pubs/44 | |
| dc.identifier.contextkey | 10048064 | |
| html.description.abstract | <p>The inheritance of information beyond DNA sequence, known as epigenetic inheritance, has been implicated in a multitude of biological processes from control of plant flowering time to cancer in humans. In addition to epigenetic inheritance that occurs in dividing cells of a multicellular organism, it is also increasingly clear that at least some epigenetic information is transmitted via the gametes in a multitude of organisms, including mammals. Here, I review the evidence for epigenetic information carriers in mammalian sperm, and explore the emerging field of intergenerational transfer of environmental information.</p> | |
| dc.identifier.submissionpath | metnet_pubs/44 | |
| dc.contributor.department | UMass Metabolic Network | |
| dc.contributor.department | Department of Biochemistry and Molecular Pharmacology |