Document Type
Journal ArticlePublication Date
2017-06-01Keywords
Mitochondrial unfolded protein responseintegrated stress response
mitochondria quality control
mitochondrial dysfunction
mitochondrial stress response
Biochemistry
Cell Biology
Cellular and Molecular Physiology
Molecular Biology
Metadata
Show full item recordAbstract
Mitochondrial function is central to many different processes in the cell, from oxidative phosphorylation to the synthesis of iron-sulfur clusters. Therefore, mitochondrial dysfunction underlies a diverse array of diseases, from neurodegenerative diseases to cancer. Stress can be communicated to the cytosol and nucleus from the mitochondria through many different signals, and in response the cell can effect everything from transcriptional to post-transcriptional responses to protect the mitochondrial network. How these responses are coordinated have only recently begun to be understood. In this review, we explore how the cell maintains mitochondrial function, focusing on the mitochondrial unfolded protein response (UPRmt), a transcriptional response that can activate a wide array of programs to repair and restore mitochondrial function.Source
Crit Rev Biochem Mol Biol. 2017 Jun;52(3):304-313. doi: 10.1080/10409238.2017.1291577. Epub 2017 Feb 22. Link to article on publisher's siteDOI
10.1080/10409238.2017.1291577Permanent Link to this Item
http://hdl.handle.net/20.500.14038/36695PubMed ID
28276702Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1080/10409238.2017.1291577