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dc.contributor.authorMurabito, Joanne M.
dc.contributor.authorRong, Jian
dc.contributor.authorLunetta, Kathryn L.
dc.contributor.authorHuan, Tianxiao
dc.contributor.authorLin, Honghuang
dc.contributor.authorZhao, Qiang
dc.contributor.authorFreedman, Jane E.
dc.contributor.authorTanriverdi, Kahraman
dc.contributor.authorLevy, Daniel
dc.contributor.authorLarson, Martin G.
dc.date2022-08-11T08:09:21.000
dc.date.accessioned2022-08-23T16:27:12Z
dc.date.available2022-08-23T16:27:12Z
dc.date.issued2017-08-01
dc.date.submitted2017-07-20
dc.identifier.citationAging Cell. 2017 Aug;16(4):888-894. doi: 10.1111/acel.12622. Epub 2017 Jun 8. <a href="https://doi.org/10.1111/acel.12622">Link to article on publisher's site</a>
dc.identifier.issn1474-9718 (Linking)
dc.identifier.doi10.1111/acel.12622
dc.identifier.pmid28597569
dc.identifier.urihttp://hdl.handle.net/20.500.14038/36729
dc.description.abstractMicroRNAs (miRNAs) regulate gene expression with emerging data suggesting miRNAs play a role in skeletal muscle biology. We sought to examine the association of miRNAs with grip strength in a community-based sample. Framingham Heart Study Offspring and Generation 3 participants (n = 5668 54% women, mean age 55 years, range 24, 90 years) underwent grip strength measurement and miRNA profiling using whole blood from fasting morning samples. Linear mixed-effects regression modeling of grip strength (kg) versus continuous miRNA 'Cq' values and versus binary miRNA expression was performed. We conducted an integrative miRNA-mRNA coexpression analysis and examined the enrichment of biologic pathways for the top miRNAs associated with grip strength. Grip strength was lower in women than in men and declined with age with a mean 44.7 (10.0) kg in men and 26.5 (6.3) kg in women. Among 299 miRNAs interrogated for association with grip strength, 93 (31%) had FDR q value < 0.05, 54 (18%) had an FDR q value < 0.01, and 15 (5%) had FDR q value < 0.001. For almost all miRNA-grip strength associations, increasing miRNA concentration is associated with increasing grip strength. miR-20a-5p (FDR q 1.8 x 10-6 ) had the most significant association and several among the top 15 miRNAs had links to skeletal muscle including miR-126-3p, miR-30a-5p, and miR-30d-5p. The top associated biologic pathways included metabolism, chemokine signaling, and ubiquitin-mediated proteolysis. Our comprehensive assessment in a community-based sample of miRNAs in blood associated with grip strength provides a framework to further our understanding of the biology of muscle strength.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=28597569&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttps://doi.org/10.1111/acel.12622
dc.rightsCopyright 2017 The Authors.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectmRNA
dc.subjectaging
dc.subjectepidemiology
dc.subjectgrip strength
dc.subjectmicroRNA
dc.subjectBiochemistry
dc.subjectCell Biology
dc.subjectCellular and Molecular Physiology
dc.subjectMolecular Biology
dc.titleCross-sectional relations of whole-blood miRNA expression levels and hand grip strength in a community sample
dc.typeJournal Article
dc.source.journaltitleAging cell
dc.source.volume16
dc.source.issue4
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1095&amp;context=metnet_pubs&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/metnet_pubs/96
dc.identifier.contextkey10458177
refterms.dateFOA2022-08-23T16:27:12Z
html.description.abstract<p>MicroRNAs (miRNAs) regulate gene expression with emerging data suggesting miRNAs play a role in skeletal muscle biology. We sought to examine the association of miRNAs with grip strength in a community-based sample. Framingham Heart Study Offspring and Generation 3 participants (n = 5668 54% women, mean age 55 years, range 24, 90 years) underwent grip strength measurement and miRNA profiling using whole blood from fasting morning samples. Linear mixed-effects regression modeling of grip strength (kg) versus continuous miRNA 'Cq' values and versus binary miRNA expression was performed. We conducted an integrative miRNA-mRNA coexpression analysis and examined the enrichment of biologic pathways for the top miRNAs associated with grip strength. Grip strength was lower in women than in men and declined with age with a mean 44.7 (10.0) kg in men and 26.5 (6.3) kg in women. Among 299 miRNAs interrogated for association with grip strength, 93 (31%) had FDR q value < 0.05, 54 (18%) had an FDR q value < 0.01, and 15 (5%) had FDR q value < 0.001. For almost all miRNA-grip strength associations, increasing miRNA concentration is associated with increasing grip strength. miR-20a-5p (FDR q 1.8 x 10-6 ) had the most significant association and several among the top 15 miRNAs had links to skeletal muscle including miR-126-3p, miR-30a-5p, and miR-30d-5p. The top associated biologic pathways included metabolism, chemokine signaling, and ubiquitin-mediated proteolysis. Our comprehensive assessment in a community-based sample of miRNAs in blood associated with grip strength provides a framework to further our understanding of the biology of muscle strength.</p>
dc.identifier.submissionpathmetnet_pubs/96
dc.contributor.departmentUMass Metabolic Network
dc.contributor.departmentDepartment of Medicine, Division of Cardiovascular Medicine
dc.source.pages888-894


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