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    Apolipoprotein E epsilon4 and incidence of Alzheimer disease in a community population of older persons.

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    Authors
    Evans, Denis A.
    Beckett, Laurel A.
    Field, Terry S.
    Feng, Lin
    Albert, Marilyn S.
    Bennett, David A.
    Tycko, Benjamin
    Mayeux, Richard
    UMass Chan Affiliations
    Meyers Primary Care Institute
    Document Type
    Journal Article
    Publication Date
    1997-03-12
    Keywords
    Aged
    Alleles
    Alzheimer Disease
    Apolipoproteins E
    Cohort Studies
    Female
    Gene Frequency
    Genotype
    Humans
    Incidence
    Logistic Models
    Male
    Multivariate Analysis
    Risk Factors
    Health Services Research
    Medicine and Health Sciences
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    Link to Full Text
    http://jama.ama-assn.org/cgi/reprint/277/10/822
    Abstract
    OBJECTIVE: To examine the relation between apolipoprotein E status and risk of Alzheimer disease (AD) in a defined population and estimate the fraction of incident AD attributable to the epsilon4 allele. DESIGN: Community-based cohort study. SETTING: East Boston, Mass. PARTICIPANTS: A random sample of 578 community residents aged 65 years and older free of AD. MAIN OUTCOME MEASURE: Clinical diagnosis of AD by uniform, structured evaluation. RESULTS: The increased risk of AD associated with the presence of the epsilon4 allele was less than that found in most family and case-control studies. Persons with the epsilon4/epsilon4 or epsilon3/epsilon4 genotypes had 2.27 (95% confidence interval, 1.06-4.89) times the risk of incident disease compared with those with the epsilon3/epsilon3 genotype. The epsilon4 allele accounted for a fairly small fraction of the incidence of AD; if the allele did not exist or had no effect on disease risk, the incidence would be reduced by only 13.7%. The effect of the epsilon4 allele on risk of AD did not appear to vary with age. CONCLUSIONS: The apolipoprotein E epsilon4 allele is an important genetic risk factor for AD but accounts for a fairly small fraction of disease occurrence in this population-based study. Continued efforts to identify other environmental and genetic risk factors are warranted.
    Source
    JAMA. 1997 Mar 12;277(10):822-4.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/36839
    PubMed ID
    9052713; 9052713
    Related Resources
    Link to article in PubMed
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    UMass Chan Faculty and Researcher Publications

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