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    Aspirin use and cognitive function in the elderly.

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    Authors
    Sturmer, Til
    Glynn, Robert J.
    Field, Terry S.
    Taylor, James O.
    Hennekens, Charles H.
    UMass Chan Affiliations
    Meyers Primary Care Institute
    Document Type
    Journal Article
    Publication Date
    1996-04-01
    Keywords
    Aged
    Aged, 80 and over
    Aspirin
    Cognition
    Confidence Intervals
    Follow-Up Studies
    Humans
    Interviews as Topic
    Logistic Models
    Massachusetts
    Memory
    Multivariate Analysis
    Odds Ratio
    Prospective Studies
    Psychological Tests
    Risk Factors
    Time Factors
    aging
    Alzheimer's Disease
    aspirin
    cognition
    cohort studies
    dementia
    multi-infarct
    incidence
    Geriatrics
    Health Services Research
    Medicine and Health Sciences
    Mental Disorders
    Nervous System
    Nervous System Diseases
    Organic Chemicals
    Pharmaceutical Preparations
    Physiological Processes
    Psychological Phenomena and Processes
    Therapeutics
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    Link to Full Text
    https://doi.org/10.1093/oxfordjournals.aje.a008801
    Abstract
    Decline in cognitive function in the elderly is common and represents a major clinical and public health concern. Aspirin may reduce the decline in cognitive function by influencing multi-infarct dementia, but data are sparse. The East Boston Senior Health Project is a population-based cohort study that enrolled 3,809 community-dwelling residents aged 65 years and older in 1982-1983 and followed them with home visits every 3 years until 1988-1989. Trained interviewers assessed cognitive function by using the Short Portable Mental Status Questionnaire and assessed medication use, including over-the-counter drugs. Response to the Short Portable Mental Status Questionnaire was scored as high, medium, or low, and decline was defined as transition to a lower category. Participants who used drugs containing aspirin in the 2 weeks prior to the interview were classified as aspirin users. Multiple logistic regression was used to obtain adjusted odds ratios and their 95% confidence intervals for decline of cognitive function. The estimating equation approach was used to adjust the standard errors for repeated measurements. Aspirin users had an odds ratio for cognitive decline of 0.97 (95% confidence interval 0.82-1.15). Low frequency of aspirin use (less than daily) was associated with an odds ratio of 0.87 (95% confidence interval 0.69-1.09). Although no substantial effect was observed, the data are also compatible with a modest benefit of aspirin, especially with intermittent use, on decline of cognitive function. Concern about small residual biases from self-selection or confounding suggests that randomized trials will be necessary to provide definitive data on this question.
    Source

    Am J Epidemiol. 1996 Apr 1;143(7):683-91.

    DOI
    10.1093/oxfordjournals.aje.a008801
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/36841
    PubMed ID
    8651230
    Related Resources

    Link to article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1093/oxfordjournals.aje.a008801
    Scopus Count
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