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dc.contributor.authorDonahue, James G.
dc.contributor.authorAndrade, Susan E.
dc.contributor.authorCain, E. M.
dc.contributor.authorDefor, T. A.
dc.contributor.authorGoodman, Michael J.
dc.contributor.authorGurwitz, Jerry H.
dc.contributor.authorPlatt, Richard
dc.date2022-08-11T08:09:21.000
dc.date.accessioned2022-08-23T16:27:47Z
dc.date.available2022-08-23T16:27:47Z
dc.date.issued1998-11-10
dc.date.submitted2011-10-21
dc.identifier.citationPharmacoepidemiol Drug Saf. 1998 Nov;7(6):415-7. DOI: 10.1002/(SICI)1099-1557(199811/12)7:6<415::AID-PDS383>3.0.CO;2-Z
dc.identifier.issn1053-8569 (Linking)
dc.identifier.doi10.1002/(SICI)1099-1557(199811/12)7:6<415::AID-PDS383>3.0.CO;2-Z
dc.identifier.pmid15073972
dc.identifier.urihttp://hdl.handle.net/20.500.14038/36866
dc.description.abstractLamotrigine is an important new addition to the drugs used to treat people with seizure disorders, but disconcerting are reports of a higher than expected incidence of severe skin reaction among children. Using automated data from three HMOs, we conducted a retrospective investigation of children (<15 >years) exposed to lamotrigine from 1 January 1995 to 30 June 1997. The outcome of interest was hospitalization for a severe skin reaction (e.g. erythema multiforme). Lamotrigine was dispensed to 124 children (56% female, mean age 8.7 years); the mean number of dispensings per person was 10. Of those exposed, 59 (47%) were hospitalized at least once during the study period, mainly for convulsions and epilepsy. There were no hospitalizations for or with a diagnosis of severe skin reactions. Our investigation revealed no evidence to support a causal relationship between lamotrigine and severe skin reactions. However, because our sample size was small we had power to detect only a very strong association between lamotrigine and severe skin disease. Taken alone, our study does not establish the risks of lamotrigine. These results should be viewed as a contribution to the totality of evidence that will be used to assess the safety of lamotrigine.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=15073972&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1002/(SICI)1099-1557(199811/12)7:6<415::AID-PDS383>3.0.CO;2-Z
dc.subjectTriazines
dc.subjectAnticonvulsants
dc.subjectDrug Eruptions
dc.subjectHealth Services Research
dc.subjectPrimary Care
dc.titleLamotrigine and severe skin eruptions
dc.typeJournal Article
dc.source.journaltitlePharmacoepidemiology and drug safety
dc.source.volume7
dc.source.issue6
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/meyers_pp/246
dc.identifier.contextkey2307207
html.description.abstract<p>Lamotrigine is an important new addition to the drugs used to treat people with seizure disorders, but disconcerting are reports of a higher than expected incidence of severe skin reaction among children. Using automated data from three HMOs, we conducted a retrospective investigation of children (<15 >years) exposed to lamotrigine from 1 January 1995 to 30 June 1997. The outcome of interest was hospitalization for a severe skin reaction (e.g. erythema multiforme). Lamotrigine was dispensed to 124 children (56% female, mean age 8.7 years); the mean number of dispensings per person was 10. Of those exposed, 59 (47%) were hospitalized at least once during the study period, mainly for convulsions and epilepsy. There were no hospitalizations for or with a diagnosis of severe skin reactions. Our investigation revealed no evidence to support a causal relationship between lamotrigine and severe skin reactions. However, because our sample size was small we had power to detect only a very strong association between lamotrigine and severe skin disease. Taken alone, our study does not establish the risks of lamotrigine. These results should be viewed as a contribution to the totality of evidence that will be used to assess the safety of lamotrigine.</p>
dc.identifier.submissionpathmeyers_pp/246
dc.contributor.departmentMeyers Primary Care Institute
dc.source.pages415-7


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