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    Compliance with pharmacologic therapy for osteoporosis

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    Authors
    Yood, Robert A.
    Emani, Srinivas
    Reed, John I.
    Lewis, Barbara Edelman
    Charpentier, Mary
    Lydick, Eva
    UMass Chan Affiliations
    Meyers Primary Care Institute
    Document Type
    Journal Article
    Publication Date
    2003-12-25
    Keywords
    Aged
    Alendronate
    Bone Density
    Bone Density Conservation Agents
    Calcitonin
    Estrogens
    Etidronic Acid
    Female
    Hip
    Humans
    Lumbar Vertebrae
    Middle Aged
    Osteoporosis, Postmenopausal
    Patient Compliance
    Treatment Outcome
    Health Services Research
    Primary Care
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    Link to Full Text
    http://dx.doi.org/10.1007/s00198-003-1502-4
    Abstract
    There is little information available concerning compliance with pharmacologic therapy for osteoporosis in the usual care setting. We evaluated 176 consecutive, previously untreated women whose physicians initiated treatment for osteoporosis following a bone mineral density (BMD) test obtained as part of routine medical practice. All patients were contacted >/=1 year after the initial BMD test and offered a follow-up BMD. Compliance with therapy was defined as the percent of time that a patient filled a prescription for osteoporosis treatment. Ninety-three (53%) patients received estrogen (ERT), 93 (53%) bisphosphonates, 8 (5%) calcitonin, and 17 (10%) received more than one therapy. Ninety-one of the 176 (52%) agreed to a follow-up BMD at a mean of 590 days after the first study (participants); 85 declined a follow-up BMD (refusers). Participants and refusers were similar for age, treatment patterns, and compliance with therapy. For all patients, compliance for those given bisphosphonate was similar to those given ERT (70.7% (95% CI 63.5-77.9%) versus 69.2% (95% CI 61.7-76.8%). For participants, the change in spine BMD was similar for those treated with bisphosphonate [mean increase 3.53 (+/-2.64)%/year (mean+/-SD)] and those treated with ERT [mean increase 3.00 (+/-2.75)%/year]. For those participants whose compliance with therapy was >/=66%, the mean increase in spine bone density was 3.80 (+/-2.59)%/year compared to 2.11 (+/-2.64)%/year ( p<0.005) for those whose compliance was <66%. Compliance with ERT and bisphosphonate therapy initiated in routine practice after a BMD was similar over a mean of 590 days. Compliance less than 66% with drug treatment results in suboptimal improvement in bone density.
    Source
    Osteoporos Int. 2003 Dec;14(12):965-8. Epub 2003 Sep 19. Link to article on publisher's site
    DOI
    10.1007/s00198-003-1502-4
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/36931
    PubMed ID
    14504697
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00198-003-1502-4
    Scopus Count
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