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dc.contributor.authorSaczynski, Jane S.
dc.contributor.authorMarcantonio, Edward R.
dc.contributor.authorQuach, Lien
dc.contributor.authorFong, Tamara G.
dc.contributor.authorGross, Alden
dc.contributor.authorInouye, Sharon K.
dc.contributor.authorJones, Richard N.
dc.date2022-08-11T08:09:23.000
dc.date.accessioned2022-08-23T16:29:03Z
dc.date.available2022-08-23T16:29:03Z
dc.date.issued2012-07-05
dc.date.submitted2012-08-09
dc.identifier.citation<p>N Engl J Med. 2012 Jul 5;367(1):30-9. <a href="http://dx.doi.org/10.1056/NEJMoa1112923" target="_blank">Link to article on publisher's site</a></p>
dc.identifier.issn0028-4793 (Linking)
dc.identifier.doi10.1056/NEJMoa1112923
dc.identifier.pmid22762316
dc.identifier.urihttp://hdl.handle.net/20.500.14038/37156
dc.description.abstractBACKGROUND: Delirium is common after cardiac surgery and may be associated with long-term changes in cognitive function. We examined postoperative delirium and the cognitive trajectory during the first year after cardiac surgery. METHODS: We enrolled 225 patients 60 years of age or older who were planning to undergo coronary-artery bypass grafting or valve replacement. Patients were assessed preoperatively, daily during hospitalization beginning on postoperative day 2, and at 1, 6, and 12 months after surgery. Cognitive function was assessed with the use of the Mini-Mental State Examination (MMSE; score range, 0 to 30, with lower scores indicating poorer performance). Delirium was diagnosed with the use of the Confusion Assessment Method. We examined performance on the MMSE in the first year after surgery, controlling for demographic characteristics, coexisting conditions, hospital, and surgery type. RESULTS: The 103 participants (46%) in whom delirium developed postoperatively had lower preoperative mean MMSE scores than those in whom delirium did not develop (25.8 vs. 26.9, P CONCLUSIONS: Delirium is associated with a significant decline in cognitive ability during the first year after cardiac surgery, with a trajectory characterized by an initial decline and prolonged impairment. (Funded by the Harvard Older Americans Independence Center and others.).
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=22762316&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1056/NEJMoa1112923
dc.rightsCopyright © 2012 Massachusetts Medical Society. PDF posted as allowed by the publisher’s Author Permissions policy at https://www.nejm.org/author-center/permissions.
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectCognition Disorders
dc.subject*Coronary Artery Bypass
dc.subjectDelirium
dc.subjectFemale
dc.subject*Heart Valve Prosthesis Implantation
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subject*Postoperative Complications
dc.subjectProspective Studies
dc.subjectPsychiatric Status Rating Scales
dc.subjectGeriatrics
dc.subjectHealth Services Research
dc.subjectPrimary Care
dc.titleCognitive trajectories after postoperative delirium
dc.typeJournal Article
dc.source.journaltitleThe New England journal of medicine
dc.source.volume367
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/meyers_pp/539
dc.identifier.contextkey3194119
refterms.dateFOA2024-03-07T16:44:10Z
html.description.abstract<p>BACKGROUND: Delirium is common after cardiac surgery and may be associated with long-term changes in cognitive function. We examined postoperative delirium and the cognitive trajectory during the first year after cardiac surgery.</p> <p>METHODS: We enrolled 225 patients 60 years of age or older who were planning to undergo coronary-artery bypass grafting or valve replacement. Patients were assessed preoperatively, daily during hospitalization beginning on postoperative day 2, and at 1, 6, and 12 months after surgery. Cognitive function was assessed with the use of the Mini-Mental State Examination (MMSE; score range, 0 to 30, with lower scores indicating poorer performance). Delirium was diagnosed with the use of the Confusion Assessment Method. We examined performance on the MMSE in the first year after surgery, controlling for demographic characteristics, coexisting conditions, hospital, and surgery type.</p> <p>RESULTS: The 103 participants (46%) in whom delirium developed postoperatively had lower preoperative mean MMSE scores than those in whom delirium did not develop (25.8 vs. 26.9, P</p> <p>CONCLUSIONS: Delirium is associated with a significant decline in cognitive ability during the first year after cardiac surgery, with a trajectory characterized by an initial decline and prolonged impairment. (Funded by the Harvard Older Americans Independence Center and others.).</p>
dc.identifier.submissionpathmeyers_pp/539
dc.contributor.departmentMeyers Primary Care Institute
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.contributor.departmentDepartment of Medicine, Division of Geriatric Medicine
dc.source.pages30-9


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