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dc.contributor.authorCunha-Cruz, Joana
dc.contributor.authorHujoel, Philippe P.
dc.contributor.authorMaupome, Gerardo
dc.contributor.authorSaver, Barry G.
dc.date2022-08-11T08:09:23.000
dc.date.accessioned2022-08-23T16:29:10Z
dc.date.available2022-08-23T16:29:10Z
dc.date.issued2008-09-01
dc.date.submitted2012-10-15
dc.identifier.citation<p>J Dent Res. 2008 Sep;87(9):871-6. <a href="http://dx.doi.org/10.1177/154405910808700916" target="_blank">Link to article on publisher's site</a></p>
dc.identifier.issn0022-0345 (Linking)
dc.identifier.doi10.1177/154405910808700916
dc.identifier.pmid18719216
dc.identifier.urihttp://hdl.handle.net/20.500.14038/37183
dc.description.abstractSystemic antibiotics have been recommended for the treatment of destructive periodontal disease. Our goal was to relate antibiotic use for medical or dental reasons to subsequent tooth loss in a cohort of 12,631 persons with destructive periodontal disease. After adjustment for age, smoking, and other confounders, the dispensing of antibiotics for 1-13 days, 14-20 days, or 21 or more days was not associated with reduced tooth loss [Adjusted rate ratio (RR) = 1.0; 95% Confidence Interval (CI) = 0.8-1.1; RR = 1.2; 95% CI = 0.9-1.4, and RR =1.2, 95% CI =1.0-1.3, respectively]. Numerous subgroup analyses were consistent with these overall null findings, with two exceptions: Longer courses of tetracyclines were associated with reduced tooth loss among persons receiving periodontal care, and penicillin was associated with reduced tooth loss among persons with more severe disease. Long-term, larger randomized trials are needed to provide evidence that antibiotics reduce tooth loss when used in the management of destructive periodontal disease.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=18719216&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577017/pdf/nihms-73410.pdf
dc.subjectAnti-Bacterial Agents
dc.subjectCase-Control Studies
dc.subjectChi-Square Distribution
dc.subjectCohort Studies
dc.subjectDrug Administration Schedule
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPeriodontal Diseases
dc.subjectRetrospective Studies
dc.subjectSeverity of Illness Index
dc.subjectTherapeutics
dc.subjectTooth Loss
dc.subjectDentistry
dc.subjectHealth Services Research
dc.subjectPrimary Care
dc.titleSystemic antibiotics and tooth loss in periodontal disease
dc.typeJournal Article
dc.source.journaltitleJournal of dental research
dc.source.volume87
dc.source.issue9
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/meyers_pp/594
dc.identifier.contextkey3393770
html.description.abstract<p>Systemic antibiotics have been recommended for the treatment of destructive periodontal disease. Our goal was to relate antibiotic use for medical or dental reasons to subsequent tooth loss in a cohort of 12,631 persons with destructive periodontal disease. After adjustment for age, smoking, and other confounders, the dispensing of antibiotics for 1-13 days, 14-20 days, or 21 or more days was not associated with reduced tooth loss [Adjusted rate ratio (RR) = 1.0; 95% Confidence Interval (CI) = 0.8-1.1; RR = 1.2; 95% CI = 0.9-1.4, and RR =1.2, 95% CI =1.0-1.3, respectively]. Numerous subgroup analyses were consistent with these overall null findings, with two exceptions: Longer courses of tetracyclines were associated with reduced tooth loss among persons receiving periodontal care, and penicillin was associated with reduced tooth loss among persons with more severe disease. Long-term, larger randomized trials are needed to provide evidence that antibiotics reduce tooth loss when used in the management of destructive periodontal disease.</p>
dc.identifier.submissionpathmeyers_pp/594
dc.contributor.departmentDepartment of Family Medicine and Community Health
dc.contributor.departmentMeyers Primary Care Institute
dc.source.pages871-6


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