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    Prevalence and trends in the use of antipsychotic medications during pregnancy in the U.S., 2001-2007: a population-based study of 585,615 deliveries

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    Authors
    Toh, Sengwee
    Li, Qian
    Cheetham, T. Craig
    Cooper, William O.
    Davis, Robert L.
    Dublin, Sascha
    Hammad, Tarek A.
    Li, De-Kun
    Pawloski, Pamala
    Pinheiro, Simone P.
    Raebel, Marsha A.
    Scott, Pamela E.
    Smith, David H.
    Bobo, William V.
    Lawrence, Jean M.
    Dashevsky, Inna
    Haffenreffer, Katherine
    Avalos, Lyndsay A.
    Andrade, Susan E.
    Show allShow less
    UMass Chan Affiliations
    Meyers Primary Care Institute
    Document Type
    Journal Article
    Publication Date
    2013-04-01
    Keywords
    Antipsychotic Agents
    Pregnancy
    Pregnancy Outcomes
    Prevalence
    Health Services Research
    Maternal and Child Health
    Mental Disorders
    Obstetrics and Gynecology
    Pharmacy and Pharmaceutical Sciences
    Psychiatry
    Women's Health
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    Link to Full Text
    http://dx.doi.org/10.1007/s00737-013-0330-6
    Abstract
    This study aims to estimate the prevalence of and temporal trends in prenatal antipsychotic medication use within a cohort of pregnant women in the U.S. We identified live born deliveries to women aged 15-45 years in 2001-2007 from 11 U.S. health plans participating in the Medication Exposure in Pregnancy Risk Evaluation Program. We ascertained prenatal exposure to antipsychotics from health plan pharmacy dispensing files, gestational age from linked infant birth certificate files, and ICD-9-CM diagnosis codes from health plan claims files. We calculated the prevalence of prenatal use of atypical and typical antipsychotics according to year of delivery, trimester of pregnancy, and mental health diagnosis. Among 585,615 qualifying deliveries, 4,223 (0.72%) were to women who received an atypical antipsychotic and 548 (0.09%) were to women receiving a typical antipsychotic any time from 60 days before pregnancy through delivery. There was a 2.5-fold increase in atypical antipsychotic use during the study period, from 0.33% (95% confidence interval: 0.29%, 0.37%) in 2001 to 0.82% (0.76%, 0.88%) in 2007, while the use of typical antipsychotics remained stable. Depression was the most common mental health diagnosis among deliveries to women with atypical antipsychotic use (63%), followed by bipolar disorder (43%) and schizophrenia (13%). The number and proportion of pregnancies exposed to atypical antipsychotics has increased dramatically in recent years. Studies are needed to examine the comparative safety and effectiveness of these medications relative to other therapeutic options in pregnancy.
    Source

    Arch Womens Ment Health. 2013 Apr;16(2):149-57. doi: 10.1007/s00737-013-0330-6. Link to article on publisher's site

    DOI
    10.1007/s00737-013-0330-6
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/37223
    PubMed ID
    23389622
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00737-013-0330-6
    Scopus Count
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