Show simple item record

dc.contributor.authorLi, Qian
dc.contributor.authorAndrade, Susan E.
dc.contributor.authorCooper, William O.
dc.contributor.authorDavis, Robert L.
dc.contributor.authorDublin, Sascha
dc.contributor.authorHammad, Tarek A.
dc.contributor.authorPawloski, Pamala
dc.contributor.authorPinheiro, Simone P.
dc.contributor.authorRaebel, Marsha A.
dc.contributor.authorScott, Pamela E.
dc.contributor.authorSmith, David H.
dc.contributor.authorDashevsky, Inna
dc.contributor.authorHaffenreffer, Katherine
dc.contributor.authorJohnson, Karin E.
dc.contributor.authorToh, Sengwee
dc.date2022-08-11T08:09:24.000
dc.date.accessioned2022-08-23T16:29:28Z
dc.date.available2022-08-23T16:29:28Z
dc.date.issued2013-05-01
dc.date.submitted2013-05-17
dc.identifier.citation<p>Pharmacoepidemiol Drug Saf. 2013 May;22(5):524-32. doi: 10.1002/pds.3407. <a href="http://dx.doi.org/10.1002/pds.3407" target="_blank">Link to article on publisher's site</a></p>
dc.identifier.issn1053-8569 (Linking)
dc.identifier.doi10.1002/pds.3407
dc.identifier.pmid23335117
dc.identifier.urihttp://hdl.handle.net/20.500.14038/37251
dc.description.abstractPURPOSE: To validate an algorithm that uses delivery date and diagnosis codes to define gestational age at birth in electronic health plan databases. METHODS: Using data from 225 384 live born deliveries to women aged 15-45 years in 2001-2007 within eight of the 11 health plans participating in the Medication Exposure in Pregnancy Risk Evaluation Program, we compared (1) the algorithm-derived gestational age versus the "gold-standard" gestational age obtained from the infant birth certificate file and (2) the prenatal exposure status of two antidepressants (fluoxetine and sertraline) and two antibiotics (amoxicillin and azithromycin) as determined by the algorithm-derived versus the gold-standard gestational age. RESULTS: The mean algorithm-derived gestational age at birth was lower than the mean obtained from the birth certificate file among singleton deliveries (267.9 vs 273.5 days) but not among multiple-gestation deliveries (253.9 vs 252.6 days). The algorithm-derived prenatal exposure to the antidepressants had a sensitivity and a positive predictive value of >/=95%, and a specificity and a negative predictive value of almost 100%. Sensitivity and positive predictive value were both >/=90%, and specificity and negative predictive value were both >99% for the antibiotics. CONCLUSIONS: A gestational age algorithm based upon electronic health plan data correctly classified medication exposure status in most live born deliveries, but trimester-specific misclassification may be higher for drugs typically used for short durations. Copyright (c) 2013 John Wiley and Sons, Ltd.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23335117&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1002/pds.3407
dc.subjectMedical Records Systems, Computerized
dc.subjectAlgorithms
dc.subjectGestational Age
dc.subjectMaternal Exposure
dc.subjectDatabases and Information Systems
dc.subjectEpidemiology
dc.subjectHealth Services Research
dc.subjectMedical Toxicology
dc.subjectPharmacy and Pharmaceutical Sciences
dc.subjectReproductive and Urinary Physiology
dc.titleValidation of an algorithm to estimate gestational age in electronic health plan databases
dc.typeJournal Article
dc.source.journaltitlePharmacoepidemiology and drug safety
dc.source.volume22
dc.source.issue5
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/meyers_pp/667
dc.identifier.contextkey4151988
html.description.abstract<p>PURPOSE: To validate an algorithm that uses delivery date and diagnosis codes to define gestational age at birth in electronic health plan databases.</p> <p>METHODS: Using data from 225 384 live born deliveries to women aged 15-45 years in 2001-2007 within eight of the 11 health plans participating in the Medication Exposure in Pregnancy Risk Evaluation Program, we compared (1) the algorithm-derived gestational age versus the "gold-standard" gestational age obtained from the infant birth certificate file and (2) the prenatal exposure status of two antidepressants (fluoxetine and sertraline) and two antibiotics (amoxicillin and azithromycin) as determined by the algorithm-derived versus the gold-standard gestational age.</p> <p>RESULTS: The mean algorithm-derived gestational age at birth was lower than the mean obtained from the birth certificate file among singleton deliveries (267.9 vs 273.5 days) but not among multiple-gestation deliveries (253.9 vs 252.6 days). The algorithm-derived prenatal exposure to the antidepressants had a sensitivity and a positive predictive value of >/=95%, and a specificity and a negative predictive value of almost 100%. Sensitivity and positive predictive value were both >/=90%, and specificity and negative predictive value were both >99% for the antibiotics.</p> <p>CONCLUSIONS: A gestational age algorithm based upon electronic health plan data correctly classified medication exposure status in most live born deliveries, but trimester-specific misclassification may be higher for drugs typically used for short durations. Copyright (c) 2013 John Wiley and Sons, Ltd.</p>
dc.identifier.submissionpathmeyers_pp/667
dc.contributor.departmentMeyers Primary Care Institute
dc.source.pages524-32


This item appears in the following Collection(s)

Show simple item record