Comprehensive evaluation of the incidence of late effects in 5-year survivors of breast cancer
dc.contributor.author | Lash, Timothy L. | |
dc.contributor.author | Thwin, Soe Soe | |
dc.contributor.author | Yood, Marianne Ulcickas | |
dc.contributor.author | Geiger, Ann M. | |
dc.contributor.author | Bosco, Jaclyn | |
dc.contributor.author | Quinn, Virginia P. | |
dc.contributor.author | Field, Terry S. | |
dc.contributor.author | Pawloski, Pamala A. | |
dc.contributor.author | Silliman, Rebecca A. | |
dc.date | 2022-08-11T08:09:24.000 | |
dc.date.accessioned | 2022-08-23T16:29:35Z | |
dc.date.available | 2022-08-23T16:29:35Z | |
dc.date.issued | 2014-04-01 | |
dc.date.submitted | 2014-10-03 | |
dc.identifier.citation | Breast Cancer Res Treat. 2014 Apr;144(3):643-63. doi: 10.1007/s10549-014-2885-y. <a href="http://dx.doi.org/10.1007/s10549-014-2885-y">Link to article on publisher's site</a> | |
dc.identifier.issn | 0167-6806 (Linking) | |
dc.identifier.doi | 10.1007/s10549-014-2885-y | |
dc.identifier.pmid | 24584822 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/37279 | |
dc.description.abstract | Late effects of breast cancer affect the quality of survivorship. Using administrative data, we compared the occurrence of almost all ICD9 codes among older breast cancer survivors to that among a matched comparison cohort to generate new hypotheses. Breast cancer patients 65 years or older diagnosed 1990-1994 in 6 integrated care settings and who survived at least 5 years were matched with a cohort of women without a history of breast cancer on care setting, age, and calendar time. We collected data on the occurrence of incident ICD9 codes beginning 6 years after the breast cancer diagnosis date and continuing to year 15, and comparable data for the matched woman. We calculated hazard ratios (HRs) and 95 % confidence intervals associating breast cancer survivorship with incidence of each ICD9 code. We used semi-Bayes methods to address multiple comparisons. Older breast cancer survivors had about the same occurrence of diseases and conditions 6-15 years after breast cancer diagnosis as comparable women. The median of 564 adjusted HRs equaled 1.06, with interquartile range 0.92-1.3. The distribution of HRs pertaining to cancer-related ICD codes was shifted toward positive associations, and the distribution pertaining to cardiovascular-related ICD codes was shifted toward negative associations. In this hypothesis-scanning study, we observed little difference in the occurrence of non-breast cancer-related diseases and conditions among older, long-term breast cancer survivors, and comparable women without a history of breast cancer. | |
dc.language.iso | en_US | |
dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=24584822&dopt=Abstract">Link to Article in PubMed</a> | |
dc.relation.url | http://dx.doi.org/10.1007/s10549-014-2885-y | |
dc.subject | Neoplasms | |
dc.subject | Oncology | |
dc.subject | Women's Health | |
dc.title | Comprehensive evaluation of the incidence of late effects in 5-year survivors of breast cancer | |
dc.type | Journal Article | |
dc.source.journaltitle | Breast cancer research and treatment | |
dc.source.volume | 144 | |
dc.source.issue | 3 | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/meyers_pp/694 | |
dc.identifier.contextkey | 6201256 | |
html.description.abstract | <p>Late effects of breast cancer affect the quality of survivorship. Using administrative data, we compared the occurrence of almost all ICD9 codes among older breast cancer survivors to that among a matched comparison cohort to generate new hypotheses. Breast cancer patients 65 years or older diagnosed 1990-1994 in 6 integrated care settings and who survived at least 5 years were matched with a cohort of women without a history of breast cancer on care setting, age, and calendar time. We collected data on the occurrence of incident ICD9 codes beginning 6 years after the breast cancer diagnosis date and continuing to year 15, and comparable data for the matched woman. We calculated hazard ratios (HRs) and 95 % confidence intervals associating breast cancer survivorship with incidence of each ICD9 code. We used semi-Bayes methods to address multiple comparisons. Older breast cancer survivors had about the same occurrence of diseases and conditions 6-15 years after breast cancer diagnosis as comparable women. The median of 564 adjusted HRs equaled 1.06, with interquartile range 0.92-1.3. The distribution of HRs pertaining to cancer-related ICD codes was shifted toward positive associations, and the distribution pertaining to cardiovascular-related ICD codes was shifted toward negative associations. In this hypothesis-scanning study, we observed little difference in the occurrence of non-breast cancer-related diseases and conditions among older, long-term breast cancer survivors, and comparable women without a history of breast cancer.</p> | |
dc.identifier.submissionpath | meyers_pp/694 | |
dc.contributor.department | Meyers Primary Care Institute | |
dc.contributor.department | Department of Medicine | |
dc.source.pages | 643-63 |