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dc.contributor.authorMcManus, David D.
dc.contributor.authorLin, Honghuang
dc.contributor.authorTanriverdi, Kahraman
dc.contributor.authorQuercio, Michael
dc.contributor.authorYin, Xiaoyan
dc.contributor.authorLarson, Martin G.
dc.contributor.authorEllinor, Patrick T.
dc.contributor.authorLevy, Daniel
dc.contributor.authorFreedman, Jane E.
dc.contributor.authorBenjamin, Emelia J.
dc.date2022-08-11T08:09:24.000
dc.date.accessioned2022-08-23T16:29:35Z
dc.date.available2022-08-23T16:29:35Z
dc.date.issued2014-01-22
dc.date.submitted2014-10-03
dc.identifier.citation<p>Heart Rhythm. 2014 Apr;11(4):663-9. doi: 10.1016/j.hrthm.2014.01.018. <a href="http://dx.doi.org/10.1016/j.hrthm.2014.01.018">Link to article on publisher's site</a></p>
dc.identifier.issn1547-5271 (Linking)
dc.identifier.doi10.1016/j.hrthm.2014.01.018
dc.identifier.pmid24444445
dc.identifier.urihttp://hdl.handle.net/20.500.14038/37280
dc.description.abstractBACKGROUND: MicroRNA (miRNA) expression in atrial tissue has been implicated in pathologic susceptibility to atrial fibrillation (AF). Nevertheless, data on how circulating levels relate to AF are limited. OBJECTIVE: The purpose of this study was to test the hypothesis that circulating miRNAs are associated with AF. METHODS: Among 2445 Framingham Heart Study Offspring participants, we measured the expression of 385 circulating whole blood miRNAs by high-throughput quantitative reverse transcriptase polymerase chain reaction. We related miRNA levels with prevalent and new-onset AF. RESULTS: Mean age of the cohort was 66.3 +/- 8.9 years, and 56% were women; 153 participants had clinically apparent AF at baseline, and 107 developed AF during median follow-up of 5.4 years. miRNA-328 (miR-328) expression was lower among participants with prevalent AF (8.76 cycle threshold) compared to individuals with no AF (7.75 cycle threshold, P < .001). The association between miR-328 and prevalent AF persisted after adjustment for age, sex, and technical covariates (odds ratio 1.21, P = 1.8 x 10(-4)) but was attenuated in analyses adjusting for clinical AF risk factors (odds ratio 1.14, P = .017). In contrast to the associations between miR-328 and prevalent AF, none of the circulating miRNAs were associated with incident AF. CONCLUSION: Circulating levels of miR-328, a miRNA known to promote atrial electrical remodeling by reducing L-type Ca(2+) channel density, were associated with prevalent AF. Adjustment for risk factors that promote atrial remodeling, including hypertension, attenuated the association between miR-328 and AF, potentially implicating miR-328 as a potential mediator of atrial remodeling and AF vulnerability. reserved.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=24444445&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219255/
dc.subjectUMCCTS funding
dc.subjectCardiology
dc.subjectCardiovascular Diseases
dc.subjectMolecular Genetics
dc.titleRelations between circulating microRNAs and atrial fibrillation: data from the Framingham Offspring Study
dc.typeJournal Article
dc.source.journaltitleHeart rhythm : the official journal of the Heart Rhythm Society
dc.source.volume11
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/meyers_pp/695
dc.identifier.contextkey6201257
html.description.abstract<p>BACKGROUND: MicroRNA (miRNA) expression in atrial tissue has been implicated in pathologic susceptibility to atrial fibrillation (AF). Nevertheless, data on how circulating levels relate to AF are limited.</p> <p>OBJECTIVE: The purpose of this study was to test the hypothesis that circulating miRNAs are associated with AF.</p> <p>METHODS: Among 2445 Framingham Heart Study Offspring participants, we measured the expression of 385 circulating whole blood miRNAs by high-throughput quantitative reverse transcriptase polymerase chain reaction. We related miRNA levels with prevalent and new-onset AF. RESULTS: Mean age of the cohort was 66.3 +/- 8.9 years, and 56% were women; 153 participants had clinically apparent AF at baseline, and 107 developed AF during median follow-up of 5.4 years. miRNA-328 (miR-328) expression was lower among participants with prevalent AF (8.76 cycle threshold) compared to individuals with no AF (7.75 cycle threshold, P < .001). The association between miR-328 and prevalent AF persisted after adjustment for age, sex, and technical covariates (odds ratio 1.21, P = 1.8 x 10(-4)) but was attenuated in analyses adjusting for clinical AF risk factors (odds ratio 1.14, P = .017). In contrast to the associations between miR-328 and prevalent AF, none of the circulating miRNAs were associated with incident AF.</p> <p>CONCLUSION: Circulating levels of miR-328, a miRNA known to promote atrial electrical remodeling by reducing L-type Ca(2+) channel density, were associated with prevalent AF. Adjustment for risk factors that promote atrial remodeling, including hypertension, attenuated the association between miR-328 and AF, potentially implicating miR-328 as a potential mediator of atrial remodeling and AF vulnerability. reserved.</p>
dc.identifier.submissionpathmeyers_pp/695
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.contributor.departmentMeyers Primary Care Institute
dc.contributor.departmentDepartment of Medicine, Division of Cardiology
dc.source.pages663-9


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