• Login
    View Item 
    •   Home
    • UMass Chan Faculty and Staff Research and Publications
    • UMass Chan Faculty and Researcher Publications
    • View Item
    •   Home
    • UMass Chan Faculty and Staff Research and Publications
    • UMass Chan Faculty and Researcher Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of eScholarship@UMassChanCommunitiesPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywordsThis CollectionPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywordsProfilesView

    My Account

    LoginRegister

    Help

    AboutSubmission GuidelinesData Deposit PolicySearchingUsage StatisticsAccessibilityTerms of UseWebsite Migration FAQ

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Whole blood gene expression and atrial fibrillation: the Framingham Heart Study

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    journal.pone.0096794.pdf
    Size:
    977.7Kb
    Format:
    PDF
    Download
    Authors
    Lin, Honghuang
    Yin, Xiaoyan
    Lunetta, Kathryn L.
    Dupuis, Josee
    McManus, David D.
    Lubitz, Steven A.
    Magnani, Jared W.
    Joehanes, Roby
    Munson, Peter J.
    Larson, Martin G.
    Levy, Daniel
    Ellinor, Patrick T.
    Benjamin, Emelia J.
    Show allShow less
    UMass Chan Affiliations
    Department of Quantitative Health Sciences, Epidemiology Division
    Meyers Primary Care Institute
    Department of Medicine, Division of Cardiovascular Medicine
    Document Type
    Journal Article
    Publication Date
    2014-05-07
    Keywords
    UMCCTS funding
    Cardiology
    Cardiovascular Diseases
    Cellular and Molecular Physiology
    Genetics
    Molecular Genetics
    
    Metadata
    Show full item record
    Abstract
    BACKGROUND: Atrial fibrillation (AF) involves substantial electrophysiological, structural and contractile remodeling. We hypothesize that characterizing gene expression might uncover important pathways related to AF. METHODS AND RESULTS: We performed genome-wide whole blood transcriptomic profiling (Affymetrix Human Exon 1.0 ST Array) of 2446 participants (mean age 66 +/- 9 years, 55% women) from the Offspring cohort of Framingham Heart Study. The study included 177 participants with prevalent AF, 143 with incident AF during up to 7 years follow up, and 2126 participants with no AF. We identified seven genes statistically significantly up-regulated with prevalent AF. The most significant gene, PBX1 (P = 2.8 x 10(-7)), plays an important role in cardiovascular development. We integrated differential gene expression with gene-gene interaction information to identify several signaling pathways possibly involved in AF-related transcriptional regulation. We did not detect any statistically significant transcriptomic associations with incident AF. CONCLUSION: We examined associations of gene expression with AF in a large community-based cohort. Our study revealed several genes and signaling pathways that are potentially involved in AF-related transcriptional regulation.
    Source
    PLoS One. 2014 May 7;9(5):e96794. doi: 10.1371/journal.pone.0096794. Link to article on publisher's site
    DOI
    10.1371/journal.pone.0096794
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/37296
    PubMed ID
    24805109
    Related Resources
    Link to Article in PubMed
    Rights

    This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0096794
    Scopus Count
    Collections
    UMass Chan Faculty and Researcher Publications
    UMass Center for Clinical and Translational Science Supported Publications

    entitlement

    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Lamar Soutter Library, UMass Chan Medical School | 55 Lake Avenue North | Worcester, MA 01655 USA
    Quick Guide | escholarship@umassmed.edu
    Works found in eScholarship@UMassChan are protected by copyright unless otherwise indicated.
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.