Show simple item record

dc.contributor.authorShen, Qiang
dc.contributor.authorMeng, Xiangjun
dc.contributor.authorFisher, Marc
dc.contributor.authorSotak, Christopher H.
dc.contributor.authorDuong, Timothy Q.
dc.date2022-08-11T08:09:26.000
dc.date.accessioned2022-08-23T16:31:06Z
dc.date.available2022-08-23T16:31:06Z
dc.date.issued2003-12-01
dc.date.submitted2008-04-17
dc.identifier.citationJ Cereb Blood Flow Metab. 2003 Dec;23(12):1479-88. <a href="http://dx.doi.org/10.1097/01.WCB.0000100064.36077.03">Link to article on publisher's site</a>
dc.identifier.issn0271-678X (Print)
dc.identifier.doi10.1097/01.WCB.0000100064.36077.03
dc.identifier.pmid14663344
dc.identifier.urihttp://hdl.handle.net/20.500.14038/37569
dc.description.abstractPixel-by-pixel spatiotemporal progression of focal ischemia (permanent occlusion) in rats was investigated using quantitative perfusion and diffusion magnetic resonance imaging every 30 minutes for 3 hours. The normal left-hemisphere apparent diffusion coefficient (ADC) was 0.76 +/- 0.03 x 10(-3) mm(2)/s and CBF was 0.7 +/- 0.3 mL x g(-1) x min(-1) (mean +/- SD, n=5). The ADC and CBF viability thresholds yielding the lesion volumes (LV) at 3 hours that best approximated the 2,3,5-triphenyltetrazolium chloride (TTC) infarct volumes (200 +/- 30 mm(3)) at 24 hours were 0.53 +/- 0.02 x 10(-3) mm(2)/s (30% +/- 2% reduction) and 0.30 +/- 0.09 mL x g(-1) x min(-1) (57% +/- 11% reduction), respectively. Temporal evolution of the ADC- and CBF-defined LV showed a significant "perfusion-diffusion mismatch" up to 2 hours (P < 0.05, n = 11), a potential therapeutic window. Based on the viability thresholds, three pixel clusters were identified on the CBF-ADC scatterplots: (1) a "normal" cluster with normal CBF and ADC, (2) an "ischemic core" cluster with markedly reduced CBF and ADC, and (3) a "mismatch" cluster with reduced CBF but slightly reduced ADC. These clusters were color-coded and mapped onto the image and CBF-ADC spaces. Lesions grew peripheral and medial to the initial ADC abnormality. In contrast to the CBF distribution, the ADC distribution in the ischemic hemisphere was bimodal; the relatively time-invariant bimodal-ADC minima were 0.57 +/- 0.02 x 10(-3) mm(2)/s (corresponding CBF 0.35 +/- 0.04 mL x g(-1) x min(-1)), surprisingly similar to the TTC-derived thresholds. Together, these results illustrate an analysis approach to systemically track the pixel-by-pixel spatiotemporal progression of acute ischemic brain injury.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14663344&dopt=Abstract ">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1097/01.WCB.0000100064.36077.03
dc.subjectAcute Disease
dc.subjectAnimals
dc.subjectBrain Ischemia
dc.subject*Cerebrovascular Circulation
dc.subjectDiffusion
dc.subjectDiffusion Magnetic Resonance Imaging
dc.subjectImage Processing, Computer-Assisted
dc.subjectMale
dc.subjectPerfusion
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectReproducibility of Results
dc.subjectStroke
dc.subjectNervous System Diseases
dc.subjectNeurology
dc.subjectRadiology
dc.titlePixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging
dc.typeJournal Article
dc.source.journaltitleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
dc.source.volume23
dc.source.issue12
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/neuro_pp/108
dc.identifier.contextkey492214
html.description.abstract<p>Pixel-by-pixel spatiotemporal progression of focal ischemia (permanent occlusion) in rats was investigated using quantitative perfusion and diffusion magnetic resonance imaging every 30 minutes for 3 hours. The normal left-hemisphere apparent diffusion coefficient (ADC) was 0.76 +/- 0.03 x 10(-3) mm(2)/s and CBF was 0.7 +/- 0.3 mL x g(-1) x min(-1) (mean +/- SD, n=5). The ADC and CBF viability thresholds yielding the lesion volumes (LV) at 3 hours that best approximated the 2,3,5-triphenyltetrazolium chloride (TTC) infarct volumes (200 +/- 30 mm(3)) at 24 hours were 0.53 +/- 0.02 x 10(-3) mm(2)/s (30% +/- 2% reduction) and 0.30 +/- 0.09 mL x g(-1) x min(-1) (57% +/- 11% reduction), respectively. Temporal evolution of the ADC- and CBF-defined LV showed a significant "perfusion-diffusion mismatch" up to 2 hours (P < 0.05, n = 11), a potential therapeutic window. Based on the viability thresholds, three pixel clusters were identified on the CBF-ADC scatterplots: (1) a "normal" cluster with normal CBF and ADC, (2) an "ischemic core" cluster with markedly reduced CBF and ADC, and (3) a "mismatch" cluster with reduced CBF but slightly reduced ADC. These clusters were color-coded and mapped onto the image and CBF-ADC spaces. Lesions grew peripheral and medial to the initial ADC abnormality. In contrast to the CBF distribution, the ADC distribution in the ischemic hemisphere was bimodal; the relatively time-invariant bimodal-ADC minima were 0.57 +/- 0.02 x 10(-3) mm(2)/s (corresponding CBF 0.35 +/- 0.04 mL x g(-1) x min(-1)), surprisingly similar to the TTC-derived thresholds. Together, these results illustrate an analysis approach to systemically track the pixel-by-pixel spatiotemporal progression of acute ischemic brain injury.</p>
dc.identifier.submissionpathneuro_pp/108
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.contributor.departmentDepartment of Radiology
dc.contributor.departmentDepartment of Neurology
dc.source.pages1479-88


This item appears in the following Collection(s)

Show simple item record