Spreading waves of decreased diffusion coefficient after cortical stimulation in the rat brain
UMass Chan Affiliations
Graduate School of Biomedical SciencesDepartment of Radiology
Department of Neurology
Document Type
Journal ArticlePublication Date
1994-08-01Keywords
AnimalsBrain
Cerebral Cortex
Diffusion
*Magnetic Resonance Spectroscopy
Male
Potassium Chloride
Rats
Rats, Sprague-Dawley
Sodium Chloride
*Spreading Cortical Depression
Neurology
Radiology
Metadata
Show full item recordAbstract
A method is demonstrated for the noninvasive detection and study of spreading cortical depression. Spreading depression (SD) was elicited in rats by topical application of potassium chloride to the exposed cortex. The apparent diffusion coefficient (Dapp) of water in a region of the cortex, measured using a PFG-NMR spin echo sequence with an observation time of 40 ms, declines 35% within 30 s and recovers to the normal value within the next 30 s. The region of decreased Dapp was shown to be 2 mm in size and to move in the cortex, away from the point of application, with a uniform velocity of 3.3 +/- 0.5 mm/min. The behavior of the affected region is consistent with other reports of the behavior of SD as monitored by electrophysiological means. The technique can be implemented on currently available MRI equipment and makes possible the noninvasive study of SD in animal models of neurological disorders, their therapeutic intervention, and possibly the study of SD in humans.Source
Magn Reson Med. 1994 Aug;32(2):189-98.
DOI
10.1002/mrm.1910320207Permanent Link to this Item
http://hdl.handle.net/20.500.14038/37593PubMed ID
7968441Related Resources
ae974a485f413a2113503eed53cd6c53
10.1002/mrm.1910320207