Atherosclerosis: current concepts on pathogenesis and interventional therapies
UMass Chan Affiliations
Department of NeurologyDocument Type
Journal ArticlePublication Date
1989-07-01Keywords
ArteriosclerosisCerebrovascular Disorders
Cholesterol
Diet
Female
Humans
Lipoproteins
Male
Nervous System Diseases
Neurology
Metadata
Show full item recordAbstract
Atherosclerosis, the primary pathological condition accounting for most stroke syndromes, has been the intense focus of epidemiological, basic, and clinical investigations. Since these studies have direct bearing on the prevention of atherothrombotic brain infarction, this review emphasizes those advances in treatment resulting from their findings. The two most prominent theories on the pathogenesis of atherosclerosis relate to aberrations in lipoprotein metabolism and to enhanced proliferation of smooth muscle cells; likely, the theories are complementary. As a practical guideline for preventive therapy, the importance of using the total cholesterol level is stressed, although finer distinctions must rely on the low-density and high-density lipoprotein concentrations and their normalization. Since prevention of stroke may ultimately be its most effective therapy, consideration of cholesterol level, akin to strategies for preventing coronary heart disease, and efforts to avert platelet adhesion or aggregation and coagulation are warranted.Source
Ann Neurol. 1989 Jul;26(1):3-12. Link to article on publisher's site
DOI
10.1002/ana.410260102Permanent Link to this Item
http://hdl.handle.net/20.500.14038/37596PubMed ID
2673002Related Resources
ae974a485f413a2113503eed53cd6c53
10.1002/ana.410260102