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dc.contributor.authorFisher, Marc
dc.contributor.authorLevine, Peter H.
dc.contributor.authorWeiner, Bonnie H.
dc.contributor.authorVaudreuil, Christine H.
dc.contributor.authorNatale, Anita M.
dc.contributor.authorJohnson, Mark H.
dc.contributor.authorHoogasian, James J.
dc.date2022-08-11T08:09:27.000
dc.date.accessioned2022-08-23T16:31:14Z
dc.date.available2022-08-23T16:31:14Z
dc.date.issued1988-04-01
dc.date.submitted2008-04-22
dc.identifier.citationInflammation. 1988 Apr;12(2):123-31.
dc.identifier.issn0360-3997 (Print)
dc.identifier.pmid2839419
dc.identifier.urihttp://hdl.handle.net/20.500.14038/37599
dc.description.abstractLipid-laden macrophages, which are predominantly derived from blood monocytes, are present at sites of active multiple sclerosis demyelination and are assumed to be involved in the demyelinating process. These inflammatory cells produce a variety of toxic oxygen metabolites which can mediate host tissue destruction. We measured production of two oxygen metabolites by monocytes and polymorphonuclear leukocytes in MS patients and controls. Stimulated monocytes produced significantly more hydrogen peroxide, superoxide, and chemiluminescence in the MS group than controls. The polymorphonuclear leukocyte, an inflammatory cell that appears to contribute little to MS demyelination, did not demonstrate increased production of toxic oxygen metabolites in the MS patients as compared to controls. These results suggest that blood monocytes in MS patients are primed to produce increased amounts of cytotoxic oxygen metabolites when exposed to inflammatory stimuli.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2839419&dopt=Abstract ">Link to article in PubMed</a>
dc.relation.urlhttp://download.springer.com/static/pdf/925/art%253A10.1007%252FBF00916395.pdf?auth66=1360619977_028f51d3ed2a986af3368759a5ae0d13&ext=.pdf
dc.subjectHumans
dc.subjectHydrogen Peroxide
dc.subjectMonocytes
dc.subjectMultiple Sclerosis
dc.subjectNeutrophils
dc.subjectSuperoxides
dc.subjectNervous System Diseases
dc.subjectNeurology
dc.titleMonocyte and polymorphonuclear leukocyte toxic oxygen metabolite production in multiple sclerosis
dc.typeJournal Article
dc.source.journaltitleInflammation
dc.source.volume12
dc.source.issue2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/neuro_pp/142
dc.identifier.contextkey495166
html.description.abstract<p>Lipid-laden macrophages, which are predominantly derived from blood monocytes, are present at sites of active multiple sclerosis demyelination and are assumed to be involved in the demyelinating process. These inflammatory cells produce a variety of toxic oxygen metabolites which can mediate host tissue destruction. We measured production of two oxygen metabolites by monocytes and polymorphonuclear leukocytes in MS patients and controls. Stimulated monocytes produced significantly more hydrogen peroxide, superoxide, and chemiluminescence in the MS group than controls. The polymorphonuclear leukocyte, an inflammatory cell that appears to contribute little to MS demyelination, did not demonstrate increased production of toxic oxygen metabolites in the MS patients as compared to controls. These results suggest that blood monocytes in MS patients are primed to produce increased amounts of cytotoxic oxygen metabolites when exposed to inflammatory stimuli.</p>
dc.identifier.submissionpathneuro_pp/142
dc.contributor.departmentDepartment of Neurology
dc.source.pages123-31


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