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dc.contributor.authorFisher, Marc
dc.contributor.authorUpchurch, Katherine S.
dc.contributor.authorLevine, Peter H.
dc.contributor.authorJohnson, Mark H.
dc.contributor.authorVaudreuil, Christine H.
dc.contributor.authorNatale, Anita M.
dc.contributor.authorHoogasian, James J.
dc.date2022-08-11T08:09:27.000
dc.date.accessioned2022-08-23T16:31:15Z
dc.date.available2022-08-23T16:31:15Z
dc.date.issued1986-12-01
dc.date.submitted2008-04-22
dc.identifier.citationInflammation. 1986 Dec;10(4):387-92.
dc.identifier.issn0360-3997 (Print)
dc.identifier.pmid3025092
dc.identifier.urihttp://hdl.handle.net/20.500.14038/37602
dc.description.abstractPolymorphonuclear leukocytes (PMNLs) are an important contributor to inflammation and are thus a part of the pathophysiology of many human diseases. We assessed the effect of fish oil on PMNL inflammatory potential by measuring chemiluminescence and superoxide production before and after six weeks of daily cod liver oil ingestion by healthy volunteers. Phagocytosing PMNLs demonstrated a 27% decrease in chemiluminescence (P less than 0.05) and a 64% decrease in superoxide production (P less than 0.01), following the cod liver oil supplementation. Analysis of PMNL and platelet fatty acids revealed the appearance of eicosapentaenoic acid and a significant decrease in arachidonic acid in both types of cells.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3025092&dopt=Abstract ">Link to article in PubMed</a>
dc.relation.urlhttp://download.springer.com/static/pdf/131/art%253A10.1007%252FBF00915822.pdf?auth66=1360622338_7c965c82a39d497b3de9e51d03fe2d2d&ext=.pdf
dc.subjectDietary Fats
dc.subjectFish Oils
dc.subjectHumans
dc.subjectInflammation
dc.subjectKinetics
dc.subjectLuminescent Measurements
dc.subjectNeutrophils
dc.subjectSuperoxides
dc.subjectImmunology and Infectious Disease
dc.subjectNeurology
dc.titleEffects of dietary fish oil supplementation on polymorphonuclear leukocyte inflammatory potential
dc.typeJournal Article
dc.source.journaltitleInflammation
dc.source.volume10
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/neuro_pp/145
dc.identifier.contextkey495169
html.description.abstract<p>Polymorphonuclear leukocytes (PMNLs) are an important contributor to inflammation and are thus a part of the pathophysiology of many human diseases. We assessed the effect of fish oil on PMNL inflammatory potential by measuring chemiluminescence and superoxide production before and after six weeks of daily cod liver oil ingestion by healthy volunteers. Phagocytosing PMNLs demonstrated a 27% decrease in chemiluminescence (P less than 0.05) and a 64% decrease in superoxide production (P less than 0.01), following the cod liver oil supplementation. Analysis of PMNL and platelet fatty acids revealed the appearance of eicosapentaenoic acid and a significant decrease in arachidonic acid in both types of cells.</p>
dc.identifier.submissionpathneuro_pp/145
dc.contributor.departmentDepartment of Medicine, Division of Rheumatology
dc.contributor.departmentDepartment of Neurology
dc.source.pages387-92


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