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dc.contributor.authorMeng, Xiangjun
dc.contributor.authorFisher, Marc
dc.contributor.authorShen, Qiang
dc.contributor.authorSotak, Christopher H.
dc.contributor.authorDuong, Timothy Q.
dc.date2022-08-11T08:09:27.000
dc.date.accessioned2022-08-23T16:31:17Z
dc.date.available2022-08-23T16:31:17Z
dc.date.issued2004-02-03
dc.date.submitted2008-04-28
dc.identifier.citationAnn Neurol. 2004 Feb;55(2):207-12. <a href="http://dx.doi.org/10.1002/ana.10803">Link to article on publisher's site</a>
dc.identifier.issn0364-5134 (Print)
dc.identifier.doi10.1002/ana.10803
dc.identifier.pmid14755724
dc.identifier.urihttp://hdl.handle.net/20.500.14038/37610
dc.description.abstractDiffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke patients. The PWI volume is typically substantially larger than the DWI volume shortly after onset, that is, a diffusion/ perfusion mismatch. The aims of this study were to follow the evolution of the diffusion/ perfusion mismatch in permanent and 60- minute temporary focal experimental ischemia models in Sprague-Dawley rats using the intraluminal middle cerebral artery occlusion (MCAO) method. DWI and arterial spin-labeled PWI were performed at 30, 60, 90, 120, and 180 minutes after occlusion and lesion volumes (mm(3)) calculated At 24 hours after MCAO, and infarct volume was determined using triphenyltetrazolium chloride staining. In the permanent MCAO group, the lesion volume on the ADC maps was significantly smaller than that on the cerebral blood flow maps through the first 60 minutes after MCAO; but not after 90 minutes of occlusion. With 60 minutes of transient ischemia, the diffusion/perfusion mismatch was similar, but after reperfusion, the lesion volumes on ADC and cerebral blood flow maps became much smaller. There was a significant difference in 24- hour infarct volumes between the permanent and temporary occlusion groups.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14755724&dopt=Abstract ">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1002/ana.10803
dc.subjectAnimals
dc.subjectBrain
dc.subjectBrain Ischemia
dc.subjectCerebrovascular Circulation
dc.subjectDiffusion
dc.subject*Diffusion Magnetic Resonance Imaging
dc.subjectDisease Models, Animal
dc.subject*Magnetic Resonance Angiography
dc.subjectMale
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectReperfusion
dc.subjectTime Factors
dc.subjectNervous System Diseases
dc.subjectNeurology
dc.titleCharacterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia
dc.typeJournal Article
dc.source.journaltitleAnnals of neurology
dc.source.volume55
dc.source.issue2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/neuro_pp/153
dc.identifier.contextkey498933
html.description.abstract<p>Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) can rapidly detect lesions in acute ischemic stroke patients. The PWI volume is typically substantially larger than the DWI volume shortly after onset, that is, a diffusion/ perfusion mismatch. The aims of this study were to follow the evolution of the diffusion/ perfusion mismatch in permanent and 60- minute temporary focal experimental ischemia models in Sprague-Dawley rats using the intraluminal middle cerebral artery occlusion (MCAO) method. DWI and arterial spin-labeled PWI were performed at 30, 60, 90, 120, and 180 minutes after occlusion and lesion volumes (mm(3)) calculated At 24 hours after MCAO, and infarct volume was determined using triphenyltetrazolium chloride staining. In the permanent MCAO group, the lesion volume on the ADC maps was significantly smaller than that on the cerebral blood flow maps through the first 60 minutes after MCAO; but not after 90 minutes of occlusion. With 60 minutes of transient ischemia, the diffusion/perfusion mismatch was similar, but after reperfusion, the lesion volumes on ADC and cerebral blood flow maps became much smaller. There was a significant difference in 24- hour infarct volumes between the permanent and temporary occlusion groups.</p>
dc.identifier.submissionpathneuro_pp/153
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.contributor.departmentDepartment of Radiology
dc.contributor.departmentDepartment of Neurology
dc.source.pages207-12


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