Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases
Arnold, Douglas L.
Cleveland, Don W.
Friedlander, Robert M.
Mouradian, M. Maral
Trapp, Bruce D.
Yong, V. Wee
UMass Chan AffiliationsDepartment of Neurology
Document TypeJournal Article
Amyotrophic Lateral Sclerosis
Magnetic Resonance Imaging
Nervous System Diseases
MetadataShow full item record
AbstractMultiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic neuron depletion; ALS, a disease of motor neuron death; and Alzheimer's, a disease of plaques and tangles. Although these disorders differ in important ways, they also have common pathogenic features, including inflammation, genetic mutations, inappropriate protein aggregates (e.g., Lewy bodies, amyloid plaques), and biochemical defects leading to apoptosis, such as oxidative stress and mitochondrial dysfunction. In most disorders, it remains uncertain whether inflammation and protein aggregation are neurotoxic or neuroprotective. Elucidating the mechanisms that orchestrate neuronal diseases should facilitate development of neuroprotective and neurorestorative strategies.
SourceJ Neuroimmunol. 2006 Jul;176(1-2):198-215.
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/37625
Related ResourcesLink to article in PubMed
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