Show simple item record

dc.contributor.authorBardutzky, Juergen F.
dc.contributor.authorShen, Qiang
dc.contributor.authorBouley, James P.
dc.contributor.authorSotak, Christopher H.
dc.contributor.authorDuong, Timothy Q.
dc.contributor.authorFisher, Marc
dc.date2022-08-11T08:09:27.000
dc.date.accessioned2022-08-23T16:31:22Z
dc.date.available2022-08-23T16:31:22Z
dc.date.issued2005-05-03
dc.date.submitted2008-04-28
dc.identifier.citationBrain Res. 2005 May 10;1043(1-2):155-62. <a href="http://dx.doi.org/10.1016/j.brainres.2005.02.073">Link to article on publisher's site</a>
dc.identifier.issn0006-8993 (Print)
dc.identifier.doi10.1016/j.brainres.2005.02.073
dc.identifier.pmid15862529
dc.identifier.urihttp://hdl.handle.net/20.500.14038/37628
dc.description.abstractHigh-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of normal, ischemic, and at-risk tissue. We compared the capability of low (400 x 400 microm(2)) and high (200 x 200 microm(2)) spatial resolution imaging in characterizing the spatiotemporal evolution of the ischemic lesion in a permanent middle artery occlusion (MCAO) model in rats. Serial measurements of cerebral blood flow (CBF) and the apparent diffusion coefficient (ADC) were performed. Lesion volumes were calculated by using viability thresholds or by visual inspection, and correlated with infarct volume defined by TTC staining at 24 h after MCAO. At the very early phase of ischemia, high-resolution resulted in a significantly larger ADC-derived lesion volume and a smaller PWI/DWI mismatch. At 3 h after MCAO, ADC and CBF lesions showed similar robust correlations with TTC-defined infarct volumes for both groups using previously established thresholds. When lesions were determined visually, low-resolution resulted in a substantial overestimation of TTC-defined infarct volume and a lower inter-observer reliability (r = 0.75), whereas high-resolution produced an excellent correlation with TTC-defined infarct volume and inter-observer reliability (r = 0.96). In conclusion, high-resolution MRI resulted in substantial temporal averaging of the ischemic lesion during the early phase, but was clearly superior in visual determination of final infarct size. Low-resolution reasonably evaluated the temporal and spatial evolution of ischemia when thresholds were used.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15862529&dopt=Abstract ">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.brainres.2005.02.073
dc.subjectAcute Disease
dc.subjectAnimals
dc.subjectBrain Ischemia
dc.subjectCarbon Dioxide
dc.subjectCerebral Cortex
dc.subjectCerebrovascular Circulation
dc.subjectHydrogen-Ion Concentration
dc.subjectInfarction, Middle Cerebral Artery
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectOxygen
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectNeurology
dc.subjectNeuroscience and Neurobiology
dc.subjectRadiology
dc.titlePerfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution
dc.typeJournal Article
dc.source.journaltitleBrain research
dc.source.volume1043
dc.source.issue1-2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/neuro_pp/171
dc.identifier.contextkey499353
html.description.abstract<p>High-resolution diffusion- (DWI) and perfusion-weighted (PWI) imaging may provide substantial benefits in accurate delineation of normal, ischemic, and at-risk tissue. We compared the capability of low (400 x 400 microm(2)) and high (200 x 200 microm(2)) spatial resolution imaging in characterizing the spatiotemporal evolution of the ischemic lesion in a permanent middle artery occlusion (MCAO) model in rats. Serial measurements of cerebral blood flow (CBF) and the apparent diffusion coefficient (ADC) were performed. Lesion volumes were calculated by using viability thresholds or by visual inspection, and correlated with infarct volume defined by TTC staining at 24 h after MCAO. At the very early phase of ischemia, high-resolution resulted in a significantly larger ADC-derived lesion volume and a smaller PWI/DWI mismatch. At 3 h after MCAO, ADC and CBF lesions showed similar robust correlations with TTC-defined infarct volumes for both groups using previously established thresholds. When lesions were determined visually, low-resolution resulted in a substantial overestimation of TTC-defined infarct volume and a lower inter-observer reliability (r = 0.75), whereas high-resolution produced an excellent correlation with TTC-defined infarct volume and inter-observer reliability (r = 0.96). In conclusion, high-resolution MRI resulted in substantial temporal averaging of the ischemic lesion during the early phase, but was clearly superior in visual determination of final infarct size. Low-resolution reasonably evaluated the temporal and spatial evolution of ischemia when thresholds were used.</p>
dc.identifier.submissionpathneuro_pp/171
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.contributor.departmentDepartment of Radiology
dc.contributor.departmentDepartment of Neurology
dc.source.pages155-62


Files in this item

Thumbnail
Name:
Publisher version

This item appears in the following Collection(s)

Show simple item record