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    Myelination and long diffusion times alter diffusion-tensor-imaging contrast in myelin-deficient shiverer mice

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    Authors
    Nair, Govind
    Tanahashi, Yusuke
    Low, Hoi Pang
    Billings-Gagliardi, Susan
    Schwartz, William J.
    Duong, Timothy Q.
    UMass Chan Affiliations
    Department of Cell Biology
    Department of Neurology
    Document Type
    Journal Article
    Publication Date
    2005-07-19
    Keywords
    Algorithms
    Animals
    Animals, Newborn
    Anisotropy
    Corpus Callosum
    Demyelinating Diseases
    *Diffusion Magnetic Resonance Imaging
    Image Processing, Computer-Assisted
    Immunohistochemistry
    Mice
    Mice, Neurologic Mutants
    Myelin Sheath
    Neural Pathways
    Neurons
    Stem Cell Transplantation
    Cell Biology
    Molecular and Cellular Neuroscience
    Radiology
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    Link to Full Text
    http://dx.doi.org/10.1016/j.neuroimage.2005.05.049
    Abstract
    Diffusion tensor imaging (DTI) using variable diffusion times (t(diff)) was performed to investigate wild-type (wt) mice, myelin-deficient shiverer (shi) mutant mice and shi mice transplanted with wt neural precursor cells that differentiate and function as oligodendrocytes. At t(diff) = 30 ms, the diffusion anisotropy "volume ratio" (VR), diffusion perpendicular to the fibers (lambda( perpendicular)), and mean apparent diffusion coefficient () of the corpus callosum of shi mice were significantly higher than those of wt mice by 12 +/- 2%, 13 +/- 2%, and 10 +/- 1%, respectively; fractional anisotropy (FA) and relative anisotropy (RA) were lower by 10 +/- 1% and 11 +/- 3%, respectively. Diffusion parallel to the fibers (lambda(//)) was not statistically different between shi and wt mice. Normalized T(2)-weighted signal intensities showed obvious differences (27 +/- 4%) between wt and shi mice in the corpus callosum but surprisingly did not detect transplant-derived myelination. In contrast, diffusion anisotropy maps detected transplant-derived myelination in the corpus callosum and its spatial distribution was consistent with the donor-derived myelination determined by immunohistochemical staining. Anisotropy indices (except lambda(//)) in the corpus callosum showed strong t(diff) dependence (30-280 ms), and the differences in lambda( perpendicular) and VR between wt and shi mice became significantly larger at longer t(diff), indicative of improved DTI sensitivity at long t(diff). In contrast, anisotropy indices in the hippocampus showed very weak t(diff) dependence and were not significantly different between wt and shi mice across different t(diff). This study provides insights into the biological signal sources and measurement parameters influencing DTI contrast, which could lead to developing more sensitive techniques for detection of demyelinating diseases.
    Source
    Neuroimage. 2005 Oct 15;28(1):165-74. Epub 2005 Jul 14. Link to article on publisher's site
    DOI
    10.1016/j.neuroimage.2005.05.049
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/37644
    PubMed ID
    16023870
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.neuroimage.2005.05.049
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