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dc.contributor.authorStrohsnitter, William C.
dc.contributor.authorSavarese, Todd M.
dc.contributor.authorLow, Hoi Pang
dc.contributor.authorChelmow, David P.
dc.contributor.authorLagiou, Pagona
dc.contributor.authorLambe, Mats
dc.contributor.authorEdmiston, Kathryn L.
dc.contributor.authorLiu, Qin
dc.contributor.authorBaik, Inkyung
dc.contributor.authorNoller, Kenneth L.
dc.contributor.authorAdami, Hans-Olov
dc.contributor.authorTrichopoulos, Dimitrios
dc.contributor.authorHsieh, Chung-Cheng
dc.date2022-08-11T08:09:27.000
dc.date.accessioned2022-08-23T16:31:27Z
dc.date.available2022-08-23T16:31:27Z
dc.date.issued2008-02-08
dc.date.submitted2008-12-18
dc.identifier.citationBr J Cancer. 2008 Feb 12;98(3):660-3. Epub 2008 Feb 5. <a href="http://dx.doi.org/10.1038/sj.bjc.6604183">Link to article on publisher's site</a>
dc.identifier.issn0007-0920 (Print)
dc.identifier.doi10.1038/sj.bjc.6604183
dc.identifier.pmid18256588
dc.identifier.urihttp://hdl.handle.net/20.500.14038/37647
dc.description.abstractWe examined the relation with birth weight and umbilical cord blood concentrations of haematopoietic stem and progenitor populations in 288 singleton infants. Across the whole range of birth weight, there was a positive relation between birth weight and CD34+CD38(-) cells, with each 500 g increase in birth weight being associated with a 15.5% higher (95% confidence interval: 1.6-31.3%) cell concentration. CD34+ and CD34+c-kit+ cells had J-shaped relations and CFU-GM cells had a U-shaped relation with birth weight. Among newborns with >or=3000 g birth weights, concentrations of these cells increased with birth weight, while those below 3000 g had higher stem cell concentrations than the reference category of 3000-3499 g. Adjustment for cord blood plasma insulin-like growth factor-1 levels weakened the stem and progenitor cell-birth weight associations. The positive associations between birth weight and stem cell measurements for term newborns with a normal-to-high birth weight support the stem cell burden hypothesis of cancer risk.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=18256588&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1038/sj.bjc.6604183
dc.subjectAntigens, CD38
dc.subject*Birth Weight
dc.subject*Blood Cell Count
dc.subjectFemale
dc.subjectFetal Blood
dc.subjectHematopoietic Stem Cells
dc.subjectHumans
dc.subjectInfant, Newborn
dc.subjectMale
dc.subjectNeoplasms
dc.subjectRisk
dc.subjectCancer Biology
dc.subjectHematology
dc.subjectObstetrics and Gynecology
dc.subjectOncology
dc.titleCorrelation of umbilical cord blood haematopoietic stem and progenitor cell levels with birth weight: implications for a prenatal influence on cancer risk
dc.typeJournal Article
dc.source.journaltitleBritish journal of cancer
dc.source.volume98
dc.source.issue3
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/neuro_pp/191
dc.identifier.contextkey683891
html.description.abstract<p>We examined the relation with birth weight and umbilical cord blood concentrations of haematopoietic stem and progenitor populations in 288 singleton infants. Across the whole range of birth weight, there was a positive relation between birth weight and CD34+CD38(-) cells, with each 500 g increase in birth weight being associated with a 15.5% higher (95% confidence interval: 1.6-31.3%) cell concentration. CD34+ and CD34+c-kit+ cells had J-shaped relations and CFU-GM cells had a U-shaped relation with birth weight. Among newborns with >or=3000 g birth weights, concentrations of these cells increased with birth weight, while those below 3000 g had higher stem cell concentrations than the reference category of 3000-3499 g. Adjustment for cord blood plasma insulin-like growth factor-1 levels weakened the stem and progenitor cell-birth weight associations. The positive associations between birth weight and stem cell measurements for term newborns with a normal-to-high birth weight support the stem cell burden hypothesis of cancer risk.</p>
dc.identifier.submissionpathneuro_pp/191
dc.contributor.departmentDepartment of Medicine, Division of Preventive and Behavioral Medicine
dc.contributor.departmentDepartment of Medicine, Division of Hematology/Oncology
dc.contributor.departmentDepartment of Cancer Biology
dc.contributor.departmentDepartment of Obstetrics and Gynecology
dc.contributor.departmentDepartment of Neurology
dc.source.pages660-3


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