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dc.contributor.authorLippa, Carol F.
dc.contributor.authorSmith, Thomas W.
dc.contributor.authorDeGirolami, Umberto
dc.contributor.authorDrachman, David A.
dc.date2022-08-11T08:09:27.000
dc.date.accessioned2022-08-23T16:31:29Z
dc.date.available2022-08-23T16:31:29Z
dc.date.issued1990-09-01
dc.date.submitted2009-06-02
dc.identifier.citation<p>Neurobiol Aging. 1990 Sep-Oct;11(5):551-4.</p>
dc.identifier.issn0197-4580 (Print)
dc.identifier.doi10.1016/0197-4580(90)90116-h
dc.identifier.pmid2234286
dc.identifier.urihttp://hdl.handle.net/20.500.14038/37659
dc.description.abstractThe histopathology of the indusium griseum (IG), a displaced hippocampal anlage, was studied in five patients with Alzheimer's disease (AD) and five controls. In the AD group, the IG had occasional neurons with granulovacuolar change (GVD) and rare Hirano bodies (HB), but no senile plaques (SP), neurofibrillary tangles (NFT), or neurons staining for phosphorylated neurofilament antigen. There was a slight but not statistically significant diminution of neurons within the IG. In all AD cases, the hippocampus showed abundant AD-associated histopathology. In the control cases, only rare neurons with GVD were present in the IG. These findings indicate that although single neurons within the IG may show some of the cytologic changes seen in the hippocampal neurons in normal aging and AD, IG neurons do not express the full range and severity of histopathologic abnormalities characteristic of AD. This suggests that factors other than selective vulnerability of neurons of hippocampal origin might be operating to induce the neuropathologic picture of AD.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=2234286&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1016/0197-4580(90)90116-h
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAlzheimer Disease
dc.subjectFemale
dc.subjectHippocampus
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectMale
dc.subjectNeurofibrils
dc.subjectNeurons
dc.subjectNeurology
dc.subjectNeuroscience and Neurobiology
dc.titleThe indusium griseum: is it involved in Alzheimer's disease
dc.typeJournal Article
dc.source.journaltitleNeurobiology of aging
dc.source.volume11
dc.source.issue5
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/neuro_pp/212
dc.identifier.contextkey861171
html.description.abstract<p>The histopathology of the indusium griseum (IG), a displaced hippocampal anlage, was studied in five patients with Alzheimer's disease (AD) and five controls. In the AD group, the IG had occasional neurons with granulovacuolar change (GVD) and rare Hirano bodies (HB), but no senile plaques (SP), neurofibrillary tangles (NFT), or neurons staining for phosphorylated neurofilament antigen. There was a slight but not statistically significant diminution of neurons within the IG. In all AD cases, the hippocampus showed abundant AD-associated histopathology. In the control cases, only rare neurons with GVD were present in the IG. These findings indicate that although single neurons within the IG may show some of the cytologic changes seen in the hippocampal neurons in normal aging and AD, IG neurons do not express the full range and severity of histopathologic abnormalities characteristic of AD. This suggests that factors other than selective vulnerability of neurons of hippocampal origin might be operating to induce the neuropathologic picture of AD.</p>
dc.identifier.submissionpathneuro_pp/212
dc.contributor.departmentDepartment of Neurology
dc.contributor.departmentDepartment of Pathology
dc.source.pages551-4


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