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    Cause or Effect: Misregulation of microRNA Pathways in Neurodegeneration

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    Authors
    Gascon, Eduardo
    Gao, Fen-Biao
    UMass Chan Affiliations
    Department of Neurology
    Document Type
    Journal Article
    Publication Date
    2012-04-09
    Keywords
    Neurodegenerative Diseases
    MicroRNAs
    Ribonuclease III
    Neurology
    Neuroscience and Neurobiology
    
    Metadata
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    Abstract
    During normal aging or neurodegenerative diseases, neuronal survival and function depend on protein homeostasis, which is regulated by multiple mechanisms, including the microRNA (miRNA) pathway. In different cells types, the absence of Dicer, a key miRNA processing enzyme, leads to neurodegeneration through cell-autonomous and non-cell-autonomous mechanisms. Loss of certain miRNAs also causes neurodegeneration in some model organisms. On the other hand, miRNA expression is misregulated in patients with different neurodegenerative diseases. Thus, the miRNA pathway appears to be essential in the pathogenesis of several age-dependent neurodegenerative conditions; however, our understanding of the underlying mechanism remains rudimentary. The precise causal relationships between specific miRNAs and neurodegeneration in humans need to be further investigated.
    Source
    Gascon E and Gao F-B (2012) Cause or effect: misregulation of microRNA pathways in neurodegeneration. Front. Neurosci. 6:48. doi: 10.3389/fnins.2012.00048. Link to article on publisher's site
    DOI
    10.3389/fnins.2012.00048
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/37734
    PubMed ID
    22509148
    Related Resources
    Link to Article in PubMed
    Rights

    Copyright: © 2012 Gascon and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

    ae974a485f413a2113503eed53cd6c53
    10.3389/fnins.2012.00048
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