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Cause or Effect: Misregulation of microRNA Pathways in Neurodegeneration

dc.contributor.authorGascon, Eduardo
dc.contributor.authorGao, Fen-Biao
dc.date2022-08-11T08:09:28.000
dc.date.accessioned2022-08-23T16:31:47Z
dc.date.available2022-08-23T16:31:47Z
dc.date.issued2012-04-09
dc.date.submitted2012-09-12
dc.identifier.citationGascon E and Gao F-B (2012) Cause or effect: misregulation of microRNA pathways in neurodegeneration. <em>Front. Neurosci.</em> <strong>6</strong>:48. doi: 10.3389/fnins.2012.00048. <a href="http://www.frontiersin.org/Neurogenomics/10.3389/fnins.2012.00048/abstract" target="_blank">Link to article on publisher's site</a>
dc.identifier.issn1662-453X (Linking)
dc.identifier.doi10.3389/fnins.2012.00048
dc.identifier.pmid22509148
dc.identifier.urihttp://hdl.handle.net/20.500.14038/37734
dc.description.abstractDuring normal aging or neurodegenerative diseases, neuronal survival and function depend on protein homeostasis, which is regulated by multiple mechanisms, including the microRNA (miRNA) pathway. In different cells types, the absence of Dicer, a key miRNA processing enzyme, leads to neurodegeneration through cell-autonomous and non-cell-autonomous mechanisms. Loss of certain miRNAs also causes neurodegeneration in some model organisms. On the other hand, miRNA expression is misregulated in patients with different neurodegenerative diseases. Thus, the miRNA pathway appears to be essential in the pathogenesis of several age-dependent neurodegenerative conditions; however, our understanding of the underlying mechanism remains rudimentary. The precise causal relationships between specific miRNAs and neurodegeneration in humans need to be further investigated.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=22509148&dopt=Abstract">Link to Article in PubMed</a>
dc.rights<p>Copyright: © 2012 Gascon and Gao. This is an open-access article distributed under the terms of the <a href="http://creativecommons.org/licenses/by-nc/3.0/">Creative Commons Attribution Non Commercial License</a>, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.</p>
dc.subjectNeurodegenerative Diseases
dc.subjectMicroRNAs
dc.subjectRibonuclease III
dc.subjectNeurology
dc.subjectNeuroscience and Neurobiology
dc.titleCause or Effect: Misregulation of microRNA Pathways in Neurodegeneration
dc.typeJournal Article
dc.source.journaltitleFrontiers in neuroscience
dc.source.volume6
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1408&amp;context=neuro_pp&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/neuro_pp/409
dc.identifier.contextkey3316119
refterms.dateFOA2022-08-23T16:31:48Z
html.description.abstract<p>During normal aging or neurodegenerative diseases, neuronal survival and function depend on protein homeostasis, which is regulated by multiple mechanisms, including the microRNA (miRNA) pathway. In different cells types, the absence of Dicer, a key miRNA processing enzyme, leads to neurodegeneration through cell-autonomous and non-cell-autonomous mechanisms. Loss of certain miRNAs also causes neurodegeneration in some model organisms. On the other hand, miRNA expression is misregulated in patients with different neurodegenerative diseases. Thus, the miRNA pathway appears to be essential in the pathogenesis of several age-dependent neurodegenerative conditions; however, our understanding of the underlying mechanism remains rudimentary. The precise causal relationships between specific miRNAs and neurodegeneration in humans need to be further investigated.</p>
dc.identifier.submissionpathneuro_pp/409
dc.contributor.departmentDepartment of Neurology
dc.source.pages48


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