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dc.contributor.authorFisher, Marc
dc.contributor.authorBastan, Birgul
dc.date2022-08-11T08:09:28.000
dc.date.accessioned2022-08-23T16:31:51Z
dc.date.available2022-08-23T16:31:51Z
dc.date.issued2012-09-25
dc.date.submitted2013-02-01
dc.identifier.citation<p>Neurology. 2012 Sep 25;79(13 Suppl 1):S79-85. <a href="http://dx.doi.org/10.1212/WNL.0b013e3182695814" target="_blank">Link to article on publisher's site</a></p>
dc.identifier.issn0028-3878 (Linking)
dc.identifier.doi10.1212/WNL.0b013e3182695814
dc.identifier.pmid23008418
dc.identifier.urihttp://hdl.handle.net/20.500.14038/37747
dc.description.abstractThe penumbral concept is defined as different areas within the ischemic region evolve into irreversible brain injury over time and that this evolution is most critically linked to the severity of the decline in cerebral blood flow (CBF). The ischemic penumbra was initially defined as a region of reduced CBF with absent spontaneous or induced electrical potentials that still maintained ionic homeostasis and transmembrane electrical potentials. The reduction of CBF levels to between 10 and 15 mL/100 g/min and approximately 25 mL/100 g/min are likely to identify penumbral tissue, and the ischemic core of irreversible ischemic tissue has a CBF value below the lower threshold. The role of identifying this critically deprived brain tissue from CBF in triaging patients for endovascular ischemic therapy is evolving. In this review we focus on the basic science of the penumbral concept and identification using various imaging modalities (PET, MRI, and CT) in animal models and human studies. Another article in this supplement addresses the clinical implication and the current understanding and application of this concept into clinical practice of endovascular ischemic stroke therapy.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23008418&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1212/WNL.0b013e3182695814
dc.subjectAnimals
dc.subjectBrain Ischemia
dc.subjectCerebrovascular Circulation
dc.subjectHumans
dc.subjectNeuroimaging
dc.subjectNervous System Diseases
dc.subjectNeurology
dc.titleIdentifying and utilizing the ischemic penumbra
dc.typeJournal Article
dc.source.journaltitleNeurology
dc.source.volume79
dc.source.issue13 Suppl 1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/neuro_pp/420
dc.identifier.contextkey3640715
html.description.abstract<p>The penumbral concept is defined as different areas within the ischemic region evolve into irreversible brain injury over time and that this evolution is most critically linked to the severity of the decline in cerebral blood flow (CBF). The ischemic penumbra was initially defined as a region of reduced CBF with absent spontaneous or induced electrical potentials that still maintained ionic homeostasis and transmembrane electrical potentials. The reduction of CBF levels to between 10 and 15 mL/100 g/min and approximately 25 mL/100 g/min are likely to identify penumbral tissue, and the ischemic core of irreversible ischemic tissue has a CBF value below the lower threshold. The role of identifying this critically deprived brain tissue from CBF in triaging patients for endovascular ischemic therapy is evolving. In this review we focus on the basic science of the penumbral concept and identification using various imaging modalities (PET, MRI, and CT) in animal models and human studies. Another article in this supplement addresses the clinical implication and the current understanding and application of this concept into clinical practice of endovascular ischemic stroke therapy.</p>
dc.identifier.submissionpathneuro_pp/420
dc.contributor.departmentDepartment of Neurology
dc.source.pagesS79-85


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