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    Nitrous oxide promotes hyperhomocysteinemia in levodopa treated rats

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    Authors
    Henninger, Nils
    Wang, Qi
    Okun, Jurgen G.
    Schwab, Stefan
    Krause, Martin
    UMass Chan Affiliations
    Department of Neurology
    Document Type
    Journal Article
    Publication Date
    2007-12-01
    Keywords
    Analgesics, Non-Narcotic
    Analysis of Variance
    Animals
    Catechols
    Drug Interactions
    Enzyme Inhibitors
    Homocysteine
    Hyperhomocysteinemia
    Immunoassay
    *Levodopa
    Male
    Nitriles
    Nitrous Oxide
    Random Allocation
    Rats
    Rats, Wistar
    Nervous System Diseases
    Neurology
    Neuroscience and Neurobiology
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    Link to Full Text
    http://dx.doi.org/10.1016/j.parkreldis.2006.11.005
    Abstract
    BACKGROUND: This study investigated whether brief exposure to nitrous oxide (N(2)O) exacerbates levodopa-induced hyperhomocysteinemia, and if co-treatment with folate or entacapone could reduce total plasma homocysteine (tHcy) levels. METHODS: Male Wistar rats (N=9 per group) were randomly treated with vehicle/N(2)O (GROUP 1), levodopa/nitrogen (group 2), levodopa/N(2)O (group 3), levodopa/N(2)O+folate (group 4), or levodopa/N(2)O+entacapone (group 5). tHcy was measured at 12 min, 4, 8, and 12 h after anesthesia. RESULTS AND CONCLUSION: The combination of N(2)O-exposure and levodopa treatment significantly increased tHcy in rats. This hyperhomocysteinemia could be prevented by entacapone but not folate co-administration.
    Source
    Parkinsonism Relat Disord. 2007 Dec;13(8):524-7. Epub 2007 Jan 19. Link to article on publisher's site
    DOI
    10.1016/j.parkreldis.2006.11.005
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/37768
    PubMed ID
    17240187
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.parkreldis.2006.11.005
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