Nitrous oxide promotes hyperhomocysteinemia in levodopa treated rats
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UMass Chan Affiliations
Department of NeurologyDocument Type
Journal ArticlePublication Date
2007-12-01Keywords
Analgesics, Non-NarcoticAnalysis of Variance
Animals
Catechols
Drug Interactions
Enzyme Inhibitors
Homocysteine
Hyperhomocysteinemia
Immunoassay
*Levodopa
Male
Nitriles
Nitrous Oxide
Random Allocation
Rats
Rats, Wistar
Nervous System Diseases
Neurology
Neuroscience and Neurobiology
Metadata
Show full item recordAbstract
BACKGROUND: This study investigated whether brief exposure to nitrous oxide (N(2)O) exacerbates levodopa-induced hyperhomocysteinemia, and if co-treatment with folate or entacapone could reduce total plasma homocysteine (tHcy) levels. METHODS: Male Wistar rats (N=9 per group) were randomly treated with vehicle/N(2)O (GROUP 1), levodopa/nitrogen (group 2), levodopa/N(2)O (group 3), levodopa/N(2)O+folate (group 4), or levodopa/N(2)O+entacapone (group 5). tHcy was measured at 12 min, 4, 8, and 12 h after anesthesia. RESULTS AND CONCLUSION: The combination of N(2)O-exposure and levodopa treatment significantly increased tHcy in rats. This hyperhomocysteinemia could be prevented by entacapone but not folate co-administration.Source
Parkinsonism Relat Disord. 2007 Dec;13(8):524-7. Epub 2007 Jan 19. Link to article on publisher's siteDOI
10.1016/j.parkreldis.2006.11.005Permanent Link to this Item
http://hdl.handle.net/20.500.14038/37768PubMed ID
17240187Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.parkreldis.2006.11.005