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    Electrophysiology and neuronal integrity following systemic arterial hypotension in a rat model of unilateral carotid artery occlusion

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    Authors
    Henninger, Nils
    Heimann, Axel
    Kempski, Oliver
    UMass Chan Affiliations
    Department of Neurology
    Document Type
    Journal Article
    Publication Date
    2007-08-13
    Keywords
    Analysis of Variance
    Animals
    Carotid Stenosis
    Cell Death
    Cortical Spreading Depression
    Disease Models, Animal
    Electroencephalography
    *Electrophysiology
    Functional Laterality
    Hypotension
    Male
    Neurons
    Rats
    Rats, Wistar
    Reaction Time
    Spectrum Analysis
    Time Factors
    Nervous System Diseases
    Neurology
    Neuroscience and Neurobiology
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    Link to Full Text
    http://dx.doi.org/10.1016/j.brainres.2007.06.006
    Abstract
    Patients with carotid artery stenosis may be particularly susceptible to hypotension-associated cerebral ischemia and subsequent neurological sequelae. Measuring somatosensory evoked potentials (SEP), electroencephalogram (EEG), direct current (DC) potential, and histology, we compared the temporal evolution of cortical functional perturbations as well as neuronal integrity in a model of unilateral carotid artery occlusion and systemic hypobaric hypotension (HH) at the lower limit of cerebral blood flow autoregulation (50 mm Hg). Serial measurements of EEG power spectra as well as SEP-amplitudes and latencies of N10.3 were performed before, during, and up to 60 min after 30 min-HH (n=7) or the control condition (n=7) in male Wistar rats. In two additional groups (with [n=7] or without [n=7] HH), cortical spreading depressions (CSD) were elicited to ascertain their contribution to brain injury. Hematoxilin-Eosin (HandE) staining was used to assess neuronal cell death at 5 days after surgery. Relative to baseline, HH attenuated ipsilateral EEG power spectrum (by maximally 62%), increased SEP-latencies (by approximately 6-10%) and amplitudes (by approximately 57-70%), and induced selective neuronal cell death in the cerebral cortex and hippocampus (P < 0.05 vs. contralateral). Spontaneous CSD occurred in approximately 30% of HH-animals. Repolarization of the DC-potential during HH was significantly prolonged relative to normotensive conditions (10.3+/-11.5 min, P < 0.001). Our model may help to understand underlying pathophysiology and improve outcome in a clinical subset of patients with carotid artery stenosis and transient systemic hypotension.
    Source
    Brain Res. 2007 Aug 13;1163:119-29. Epub 2007 Jun 16. Link to article on publisher's site
    DOI
    10.1016/j.brainres.2007.06.006
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/37770
    PubMed ID
    17632088
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.brainres.2007.06.006
    Scopus Count
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