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dc.contributor.authorGerriets, Tibo
dc.contributor.authorStolz, Erwin
dc.contributor.authorWalberer, Maureen
dc.contributor.authorMuller, Clemens
dc.contributor.authorKluge, Alexander
dc.contributor.authorBachmann, A.
dc.contributor.authorFisher, Marc
dc.contributor.authorKaps, Manfred
dc.contributor.authorBachmann, Georg
dc.date2022-08-11T08:09:28.000
dc.date.accessioned2022-08-23T16:32:01Z
dc.date.available2022-08-23T16:32:01Z
dc.date.issued2004-02-01
dc.date.submitted2008-04-07
dc.identifier.citationStroke. 2004 Feb;35(2):566-71. Epub 2004 Jan 22. <a href="http://dx.doi.org/10.1161/01.STR.0000113692.38574.57">Link to article on publisher's site</a>
dc.identifier.issn1524-4628 (Electronic)
dc.identifier.doi10.1161/01.STR.0000113692.38574.57
dc.identifier.pmid14739415
dc.identifier.urihttp://hdl.handle.net/20.500.14038/37789
dc.description.abstractBACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an extension of the affected tissue. The space-occupying effect due to brain edema can be quantified in rat stroke models with the use of MRI. The present study was performed to test 2 hypotheses: (1) Can quantification of the space-occupying effect due to brain edema serve as a noninvasive measure for brain water content? (2) Does morphometric assessment of brain swelling allow determination of true infarct size on MRI after correction for the space-occupying effect of edema? METHODS: Thirty rats were subjected to permanent suture middle cerebral artery occlusion. MRI was performed after 6 or 24 hours, and hemispheric swelling was assessed morphometrically. Interobserver and intraobserver agreements were determined for MRI measurements. In study I, the space-occupying effect due to brain edema was correlated with the absolute brain water content by the wet/dry method. In study II, lesion volumes corrected and uncorrected for edema were calculated on MRI and on TTC staining and compared. RESULTS: Interobserver and intraobserver agreements for MRI measurements were excellent (r>or=0.97). Brain water content and hemispheric swelling correlated well after 6 and 24 hours (r>or=0.95). Corrected lesion volumes correlated with r=0.78 between TTC staining and MRI. Without edema correction, lesion volumes were overestimated by 20.3% after 6 hours and by 29.6% after 24 hours of ischemia. CONCLUSIONS: Morphometric assessment of hemispheric swelling on MRI can determine the increase in absolute brain water content noninvasively and can also provide ischemic lesion volumes corrected for brain edema.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14739415&dopt=Abstract ">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1161/01.STR.0000113692.38574.57
dc.subjectAnimals
dc.subjectBrain
dc.subjectBrain Edema
dc.subjectDisease Models, Animal
dc.subjectDisease Progression
dc.subjectInfarction, Middle Cerebral Artery
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectObserver Variation
dc.subjectPilot Projects
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectReproducibility of Results
dc.subjectStroke
dc.subjectWater
dc.titleNoninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging
dc.typeJournal Article
dc.source.journaltitleStroke; a journal of cerebral circulation
dc.source.volume35
dc.source.issue2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/neuro_pp/56
dc.identifier.contextkey483780
html.description.abstract<p>BACKGROUND AND PURPOSE: Brain edema is a life-threatening consequence of stroke and leads to an extension of the affected tissue. The space-occupying effect due to brain edema can be quantified in rat stroke models with the use of MRI. The present study was performed to test 2 hypotheses: (1) Can quantification of the space-occupying effect due to brain edema serve as a noninvasive measure for brain water content? (2) Does morphometric assessment of brain swelling allow determination of true infarct size on MRI after correction for the space-occupying effect of edema?</p> <p>METHODS: Thirty rats were subjected to permanent suture middle cerebral artery occlusion. MRI was performed after 6 or 24 hours, and hemispheric swelling was assessed morphometrically. Interobserver and intraobserver agreements were determined for MRI measurements. In study I, the space-occupying effect due to brain edema was correlated with the absolute brain water content by the wet/dry method. In study II, lesion volumes corrected and uncorrected for edema were calculated on MRI and on TTC staining and compared.</p> <p>RESULTS: Interobserver and intraobserver agreements for MRI measurements were excellent (r>or=0.97). Brain water content and hemispheric swelling correlated well after 6 and 24 hours (r>or=0.95). Corrected lesion volumes correlated with r=0.78 between TTC staining and MRI. Without edema correction, lesion volumes were overestimated by 20.3% after 6 hours and by 29.6% after 24 hours of ischemia.</p> <p>CONCLUSIONS: Morphometric assessment of hemispheric swelling on MRI can determine the increase in absolute brain water content noninvasively and can also provide ischemic lesion volumes corrected for brain edema.</p>
dc.identifier.submissionpathneuro_pp/56
dc.contributor.departmentDepartment of Neurology
dc.source.pages566-71


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