Show simple item record

dc.contributor.authorAli, Myzoon
dc.contributor.authorBath, Philip M.W.
dc.contributor.authorCurram, John
dc.contributor.authorDavis, Stephen M.
dc.contributor.authorDiener, Hans-Christoph
dc.contributor.authorDonnan, Geoffrey A.
dc.contributor.authorFisher, Marc
dc.contributor.authorGregson, Barbara A.
dc.contributor.authorGrotta, James
dc.contributor.authorHacke, Werner
dc.contributor.authorHennerici, Michael G.
dc.contributor.authorHommel, Marc
dc.contributor.authorKaste, Markku
dc.contributor.authorMarler, John R.
dc.contributor.authorSacco, Ralph L.
dc.contributor.authorTeal, Philip
dc.contributor.authorWahlgren, Nils-Gunnar
dc.contributor.authorWarach, Steven
dc.contributor.authorWeir, Christopher J.
dc.contributor.authorLees, Kennedy R.
dc.date2022-08-11T08:09:28.000
dc.date.accessioned2022-08-23T16:32:04Z
dc.date.available2022-08-23T16:32:04Z
dc.date.issued2007-06-01
dc.date.submitted2008-04-07
dc.identifier.citationStroke. 2007 Jun;38(6):1905-10. Epub 2007 Apr 19. <a href="http://dx.doi.org/10.1161/STROKEAHA.106.473579">Link to article on publisher's site</a>
dc.identifier.issn1524-4628 (Electronic)
dc.identifier.doi10.1161/STROKEAHA.106.473579
dc.identifier.pmid17446430
dc.identifier.urihttp://hdl.handle.net/20.500.14038/37799
dc.description.abstractBACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs highlights the need for reliable data on which to plan future clinical trials. The Virtual International Stroke Trials Archive aims to aid the planning of clinical trials by collating and providing access to a rich resource of patient data to perform exploratory analyses. METHODS: Data were contributed by the principal investigators of numerous trials from the past 16 years. These data have been centrally collated and are available for anonymized analysis and hypothesis testing. RESULTS: Currently, the Virtual International Stroke Trials Archive contains 21 trials. There are data on >15,000 patients with both ischemic and hemorrhagic stroke. Ages range between 18 and 103 years, with a mean age of 69+/-12 years. Outcome measures include the Barthel Index, Scandinavian Stroke Scale, National Institutes of Health Stroke Scale, Orgogozo Scale, and modified Rankin Scale. Medical history and onset-to-treatment time are readily available, and computed tomography lesion data are available for selected trials. CONCLUSIONS: This resource has the potential to influence clinical trial design and implementation through data analyses that inform planning.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17446430&dopt=Abstract ">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1161/STROKEAHA.106.473579
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subject*Archives
dc.subjectFemale
dc.subjectHumans
dc.subjectInternationality
dc.subjectMale
dc.subjectMiddle Aged
dc.subject*Randomized Controlled Trials as Topic
dc.subjectStroke
dc.subjectNervous System Diseases
dc.subjectNeurology
dc.titleThe Virtual International Stroke Trials Archive
dc.typeArticle
dc.source.journaltitleStroke; a journal of cerebral circulation
dc.source.volume38
dc.source.issue6
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/neuro_pp/67
dc.identifier.contextkey483791
html.description.abstract<p>BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs highlights the need for reliable data on which to plan future clinical trials. The Virtual International Stroke Trials Archive aims to aid the planning of clinical trials by collating and providing access to a rich resource of patient data to perform exploratory analyses.</p> <p>METHODS: Data were contributed by the principal investigators of numerous trials from the past 16 years. These data have been centrally collated and are available for anonymized analysis and hypothesis testing.</p> <p>RESULTS: Currently, the Virtual International Stroke Trials Archive contains 21 trials. There are data on >15,000 patients with both ischemic and hemorrhagic stroke. Ages range between 18 and 103 years, with a mean age of 69+/-12 years. Outcome measures include the Barthel Index, Scandinavian Stroke Scale, National Institutes of Health Stroke Scale, Orgogozo Scale, and modified Rankin Scale. Medical history and onset-to-treatment time are readily available, and computed tomography lesion data are available for selected trials.</p> <p>CONCLUSIONS: This resource has the potential to influence clinical trial design and implementation through data analyses that inform planning.</p>
dc.identifier.submissionpathneuro_pp/67
dc.contributor.departmentDepartment of Neurology
dc.source.pages1905-10


This item appears in the following Collection(s)

Show simple item record