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dc.contributor.authorReith, W.
dc.contributor.authorHasegawa, Yasuhiro
dc.contributor.authorLatour, Lawrence L.
dc.contributor.authorDardzinski, Bernard J.
dc.contributor.authorSotak, Christopher H.
dc.contributor.authorFisher, Marc
dc.date2022-08-11T08:09:28.000
dc.date.accessioned2022-08-23T16:32:07Z
dc.date.available2022-08-23T16:32:07Z
dc.date.issued1995-01-01
dc.date.submitted2008-04-14
dc.identifier.citationNeurology. 1995 Jan;45(1):172-7.
dc.identifier.issn0028-3878 (Print)
dc.identifier.pmid7824111
dc.identifier.urihttp://hdl.handle.net/20.500.14038/37813
dc.description.abstractDiffusion-weighted magnetic resonance imaging (DWI) can quantitatively demonstrate cerebral ischemia within minutes after the onset of ischemia. The use of a DWI echo-planar multislice technique in this study and the mapping of the apparent diffusion coefficient (ADC) of water, a reliable indicator of ischemic regions, allow for the detection of the three-dimensional (3-D) evolution of ischemia in a rat stroke model. We evaluated 13 time points from 5 to 180 minutes after occlusion of the middle cerebral artery (MCA) and monitored the 3-D spread of ischemia. Within 5 minutes after the onset of ischemia, regions with reduced ADC values occurred. The core of the lesion, with the lowest absolute ADC values, first appeared in the lateral caudoputamen and frontoparietal cortex, then spread to adjacent areas. The volume of ischemic tissue was 224 +/- 48.5 mm3 (mean +/- SEM) after 180 minutes, ranging from 92 to 320 mm3, and this correlated well with the corrected infarct volume at postmortem (194 +/- 23.1 mm3, r = 0.72, p < 0.05). This experiment demonstrated that 3-D multislice diffusion mapping can detect ischemic regions noninvasively 5 minutes after MCA occlusion and follow the development of ischemia. The distribution of changes in absolute ADC values within the ischemic region can be followed over time, giving important information about the evolution of focal ischemia.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7824111&dopt=Abstract ">Link to article in PubMed</a>
dc.relation.urlhttp://www.neurology.org/content/45/1/172.full.pdf+html
dc.subjectAnimals
dc.subjectBrain
dc.subjectBrain Ischemia
dc.subjectCerebral Arteries
dc.subjectCerebrovascular Disorders
dc.subjectDisease Models, Animal
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectTime Factors
dc.subjectNervous System Diseases
dc.subjectNeurology
dc.subjectRadiology
dc.titleMultislice diffusion mapping for 3-D evolution of cerebral ischemia in a rat stroke model
dc.typeArticle
dc.source.journaltitleNeurology
dc.source.volume45
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/neuro_pp/81
dc.identifier.contextkey489707
html.description.abstract<p>Diffusion-weighted magnetic resonance imaging (DWI) can quantitatively demonstrate cerebral ischemia within minutes after the onset of ischemia. The use of a DWI echo-planar multislice technique in this study and the mapping of the apparent diffusion coefficient (ADC) of water, a reliable indicator of ischemic regions, allow for the detection of the three-dimensional (3-D) evolution of ischemia in a rat stroke model. We evaluated 13 time points from 5 to 180 minutes after occlusion of the middle cerebral artery (MCA) and monitored the 3-D spread of ischemia. Within 5 minutes after the onset of ischemia, regions with reduced ADC values occurred. The core of the lesion, with the lowest absolute ADC values, first appeared in the lateral caudoputamen and frontoparietal cortex, then spread to adjacent areas. The volume of ischemic tissue was 224 +/- 48.5 mm3 (mean +/- SEM) after 180 minutes, ranging from 92 to 320 mm3, and this correlated well with the corrected infarct volume at postmortem (194 +/- 23.1 mm3, r = 0.72, p < 0.05). This experiment demonstrated that 3-D multislice diffusion mapping can detect ischemic regions noninvasively 5 minutes after MCA occlusion and follow the development of ischemia. The distribution of changes in absolute ADC values within the ischemic region can be followed over time, giving important information about the evolution of focal ischemia.</p>
dc.identifier.submissionpathneuro_pp/81
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.contributor.departmentDepartment of Radiology
dc.contributor.departmentDepartment of Neurology
dc.source.pages172-7


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