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    Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging

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    Authors
    Takano, Kentaro
    Carano, Richard A.D.
    Tatlisumak, Turgut
    Meiler, Michael R.
    Sotak, Christopher H.
    Kleinert, H. D.
    Fisher, Marc
    UMass Chan Affiliations
    Graduate School of Biomedical Sciences
    Department of Radiology
    Department of Neurology
    Document Type
    Journal Article
    Publication Date
    1998-04-01
    Keywords
    Animals
    Cerebral Infarction
    Cerebrovascular Circulation
    Cerebrovascular Disorders
    Disease Models, Animal
    Injections, Intra-Arterial
    Injections, Intravenous
    Intracranial Embolism and Thrombosis
    Magnetic Resonance Imaging
    Male
    Plasminogen Activators
    Rats
    Rats, Sprague-Dawley
    Recombinant Proteins
    Reperfusion
    Urinary Plasminogen Activator
    Neurology
    Neuroscience and Neurobiology
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    Link to Full Text
    http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006114-199804000-00013&LSLINK=80&D=ovft
    Abstract
    OBJECTIVE: To explore the utility of intravenous (i.v.) prourokinase treatment, we compared intra-arterial (i.a.) and i.v. delivery in a rat embolic stroke model, using diffusion (DWI) and perfusion (PI) magnetic resonance imaging to assess in vivo effects on ischemic lesion evolution and reperfusion. BACKGROUND: Thrombolytic therapy with recombinant tissue-type plasminogen activator (rt-PA) for acute ischemic stroke is useful during the initial hours after onset. Prourokinase is a novel thrombolytic agent with potential safety advantages in comparison to rt-PA. METHODS: Twenty-four male Sprague-Dawley rats were embolized with autologous blood clots into the middle cerebral artery territory and then randomly assigned at 30 minutes after embolization to a 2-hour bolus infusion with i.a. prourokinase, i.v. prourokinase, or vehicle. DWI and PI were performed before treatment and repeated during and at the end of the treatment. RESULTS: PI demonstrated that both i.a. and i.v. significantly improved the percentage of the ischemic hemisphere that was normally perfused when the 20-minute, pretreatment, and 145-minute after embolization time points were compared; in the control group, the hypoperfused volume increased over time. DWI disclosed that the ischemic lesion evolution slightly decreased in the i.a. group, remained stable in the i.v. group, and increased over time in the control group. Infarct volume by triphenyltetrazolium chloride (TTC) staining was significantly smaller in both treatment groups than controls. CONCLUSIONS: These results demonstrate that i.a. and i.v. therapy with prourokinase are equally effective in promoting reperfusion and inhibiting the development of focal ischemic injury in this rat embolic stroke model.
    Source
    Neurology. 1998 Apr;50(4):870-5.>
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/37818
    PubMed ID
    9566365
    Related Resources
    Link to article in PubMed
    Collections
    Morningside Graduate School of Biomedical Sciences Scholarly Publications
    UMass Chan Faculty and Researcher Publications
    Radiology Publications

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