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dc.contributor.authorLin, Suewei
dc.contributor.authorLee, Tzumin
dc.date2022-08-11T08:09:29.000
dc.date.accessioned2022-08-23T16:32:19Z
dc.date.available2022-08-23T16:32:19Z
dc.date.issued2012-01-01
dc.date.submitted2012-09-12
dc.identifier.citationDev Dyn. 2012 Jan;241(1):57-68. doi: 10.1002/dvdy.22739. Epub 2011 Sep 19. <a href="http://dx.doi.org/10.1002/dvdy.22739">Link to article on publisher's site</a>
dc.identifier.issn1058-8388 (Linking)
dc.identifier.doi10.1002/dvdy.22739
dc.identifier.pmid21932323
dc.identifier.urihttp://hdl.handle.net/20.500.14038/37860
dc.description<p>Co-author Suewei Lin is a student in the Neuroscience program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.</p>
dc.description.abstractGenerating diverse neurons in the central nervous system involves three major steps. First, heterogeneous neural progenitors are specified by positional cues at early embryonic stages. Second, neural progenitors sequentially produce neurons or intermediate precursors that acquire different temporal identities based on their birth-order. Third, sister neurons produced during asymmetrical terminal mitoses are given distinct fates. Determining the molecular mechanisms underlying each of these three steps of cellular diversification will unravel brain development and evolution. Drosophila has a relatively simple and tractable CNS, and previous studies on Drosophila CNS development have greatly advanced our understanding of neuron fate specification. Here we review those studies and discuss how the lessons we have learned from fly teach us the process of neuronal diversification in general.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=21932323&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1002/dvdy.22739
dc.subjectAnimals
dc.subjectCell Lineage
dc.subjectCentral Nervous System
dc.subjectDrosophila Proteins
dc.subjectDrosophila melanogaster
dc.subjectMorphogenesis
dc.subjectNeurogenesis
dc.subjectNeurons
dc.subjectStem Cells
dc.subjectNeuroscience and Neurobiology
dc.titleGenerating neuronal diversity in the Drosophila central nervous system
dc.typeJournal Article
dc.source.journaltitleDevelopmental dynamics : an official publication of the American Association of Anatomists
dc.source.volume241
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/neurobiology_pp/129
dc.identifier.contextkey3315320
html.description.abstract<p>Generating diverse neurons in the central nervous system involves three major steps. First, heterogeneous neural progenitors are specified by positional cues at early embryonic stages. Second, neural progenitors sequentially produce neurons or intermediate precursors that acquire different temporal identities based on their birth-order. Third, sister neurons produced during asymmetrical terminal mitoses are given distinct fates. Determining the molecular mechanisms underlying each of these three steps of cellular diversification will unravel brain development and evolution. Drosophila has a relatively simple and tractable CNS, and previous studies on Drosophila CNS development have greatly advanced our understanding of neuron fate specification. Here we review those studies and discuss how the lessons we have learned from fly teach us the process of neuronal diversification in general.</p>
dc.identifier.submissionpathneurobiology_pp/129
dc.contributor.departmentGraduate School of Biomedical Sciences, Neuroscience Program
dc.contributor.departmentLee Lab
dc.contributor.departmentNeurobiology
dc.source.pages57-68
dc.contributor.studentSuewei Lin
dc.description.thesisprogramNeuroscience


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