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dc.contributor.authorAwasaki, Takeshi
dc.contributor.authorHuang, Ya-ling
dc.contributor.authorO'Connor, Michael B.
dc.contributor.authorLee, Tzumin
dc.date2022-08-11T08:09:29.000
dc.date.accessioned2022-08-23T16:32:20Z
dc.date.available2022-08-23T16:32:20Z
dc.date.issued2011-06-19
dc.date.submitted2012-09-12
dc.identifier.citationNat Neurosci. 2011 Jun 19;14(7):821-3. doi: 10.1038/nn.2833. <a href="http://dx.doi.org/10.1038/nn.2833">Link to article on publisher's site</a>
dc.identifier.issn1097-6256 (Linking)
dc.identifier.doi10.1038/nn.2833
dc.identifier.pmid21685919
dc.identifier.urihttp://hdl.handle.net/20.500.14038/37862
dc.description.abstractWe found that glia secrete myoglianin, a TGF-beta ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=21685919&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337551/pdf/nihms-288189.pdf
dc.subjectAnimals
dc.subjectAnimals, Genetically Modified
dc.subjectDrosophila
dc.subjectDrosophila Proteins
dc.subjectGene Expression Regulation, Developmental
dc.subjectGreen Fluorescent Proteins
dc.subjectMicroRNAs
dc.subject*Models, Neurological
dc.subjectMushroom Bodies
dc.subjectMutation
dc.subjectNeurogenesis
dc.subjectNeuroglia
dc.subjectRNA, Double-Stranded
dc.subjectSignal Transduction
dc.subjectTransforming Growth Factor beta
dc.subjectNeuroscience and Neurobiology
dc.titleGlia instruct developmental neuronal remodeling through TGF-beta signaling
dc.typeJournal Article
dc.source.journaltitleNature neuroscience
dc.source.volume14
dc.source.issue7
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/neurobiology_pp/131
dc.identifier.contextkey3315324
html.description.abstract<p>We found that glia secrete myoglianin, a TGF-beta ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.</p>
dc.identifier.submissionpathneurobiology_pp/131
dc.contributor.departmentLee Lab
dc.contributor.departmentNeurobiology
dc.source.pages821-3


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