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dc.contributor.authorKalra, Hina
dc.contributor.authorBudnik, Vivian
dc.contributor.authorMathivanan, Suresh
dc.date2022-08-11T08:09:29.000
dc.date.accessioned2022-08-23T16:32:20Z
dc.date.available2022-08-23T16:32:20Z
dc.date.issued2012-12-29
dc.date.submitted2013-01-23
dc.identifier.citationPLoS Biol. 2012 Dec;10(12):e1001450. doi: 10.1371/journal.pbio.1001450. <a href="http://dx.doi.org/10.1371/journal.pbio.1001450" target="_blank">Link to article on publisher's site</a>
dc.identifier.issn1544-9173 (Linking)
dc.identifier.doi10.1371/journal.pbio.1001450
dc.identifier.pmid23271954
dc.identifier.urihttp://hdl.handle.net/20.500.14038/37864
dc.description<p>Full author list omitted for brevity. For the full list of authors, see article.</p>
dc.description.abstractExtracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, and as possible reservoirs of biomarkers. These findings have generated immense interest, along with an exponential increase in molecular data pertaining to EVs. Here, we describe Vesiclepedia, a manually curated compendium of molecular data (lipid, RNA, and protein) identified in different classes of EVs from more than 300 independent studies published over the past several years. Even though databases are indispensable resources for the scientific community, recent studies have shown that more than 50% of the databases are not regularly updated. In addition, more than 20% of the database links are inactive. To prevent such database and link decay, we have initiated a continuous community annotation project with the active involvement of EV researchers. The EV research community can set a gold standard in data sharing with Vesiclepedia, which could evolve as a primary resource for the field.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23271954&dopt=Abstract">Link to Article in PubMed</a>
dc.rightsCopyright 2012 Kalra et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.subjectCytoplasmic Vesicles
dc.subjectNeuroscience and Neurobiology
dc.titleVesiclepedia: a compendium for extracellular vesicles with continuous community annotation
dc.typeJournal Article
dc.source.journaltitlePLoS biology
dc.source.volume10
dc.source.issue12
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1134&amp;context=neurobiology_pp&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/neurobiology_pp/135
dc.identifier.contextkey3608529
refterms.dateFOA2022-08-23T16:32:21Z
html.description.abstract<p>Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, and as possible reservoirs of biomarkers. These findings have generated immense interest, along with an exponential increase in molecular data pertaining to EVs. Here, we describe Vesiclepedia, a manually curated compendium of molecular data (lipid, RNA, and protein) identified in different classes of EVs from more than 300 independent studies published over the past several years. Even though databases are indispensable resources for the scientific community, recent studies have shown that more than 50% of the databases are not regularly updated. In addition, more than 20% of the database links are inactive. To prevent such database and link decay, we have initiated a continuous community annotation project with the active involvement of EV researchers. The EV research community can set a gold standard in data sharing with Vesiclepedia, which could evolve as a primary resource for the field.</p>
dc.identifier.submissionpathneurobiology_pp/135
dc.contributor.departmentBudnik Lab
dc.contributor.departmentNeurobiology
dc.source.pagese1001450


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