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Circadian rhythm of temperature preference and its neural control in Drosophila
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Authors
Kaneko, HarunaHead, Lauren M.
Ling, Jinli
Tang, Xin
Liu, Yilin
Hardin, Paul E.
Emery, Patrick
Hamada, Fumika N.
Student Authors
Jinli LingAcademic Program
NeuroscienceDocument Type
Journal ArticlePublication Date
2012-10-09
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Show full item recordAbstract
A daily body temperature rhythm (BTR) is critical for the maintenance of homeostasis in mammals. Whereas mammals use internal energy to regulate body temperature, ectotherms typically regulate body temperature behaviorally [1]. Some ectotherms maintain homeostasis via a daily temperature preference rhythm (TPR) [2], but the underlying mechanisms are largely unknown. Here, we show that Drosophila exhibit a daily circadian clock-dependent TPR that resembles mammalian BTR. Pacemaker neurons critical for locomotor activity are not necessary for TPR; instead, the dorsal neuron 2 s (DN2s), whose function was previously unknown, is sufficient. This indicates that TPR, like BTR, is controlled independently from locomotor activity. Therefore, the mechanisms controlling temperature fluctuations in fly TPR and mammalian BTR may share parallel features. Taken together, our results reveal the existence of a novel DN2-based circadian neural circuit that specifically regulates TPR; thus, understanding the mechanisms of TPR will shed new light on the function and neural control of circadian rhythms.Source
Curr Biol. 2012 Oct 9;22(19):1851-7. doi: 10.1016/j.cub.2012.08.006. Link to article on publisher's siteDOI
10.1016/j.cub.2012.08.006Permanent Link to this Item
http://hdl.handle.net/20.500.14038/37868PubMed ID
22981774Notes
Co-author Jinli Ling is a doctoral student in the Neuroscience Program in the Morningside Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.
Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.cub.2012.08.006