Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications
Authors
Wu, XiangZhang, Yuanwei
Takle, Kendra
Bilsel, Osman
Li, Zhan Jun
Lee, Hyungseok
Lois, Carlos
Xiang, Yang
Han, Gang
UMass Chan Affiliations
Graduate School of Biomedical Sciences, Neuroscience ProgramLois Lab
Yang Xiang Lab
Neurobiology
Biochemistry and Molecular Pharmacology
Document Type
Journal ArticlePublication Date
2016-01-26Keywords
bioimagingcore/active shell structure
dye-sensitizing
near-infrared
optogenetics
upconversion nanoparticles
Medicinal-Pharmaceutical Chemistry
Nanomedicine
Neuroscience and Neurobiology
Metadata
Show full item recordAbstract
Near-infrared (NIR) dye-sensitized upconversion nanoparticles (UCNPs) can broaden the absorption range and boost upconversion efficiency of UCNPs. Here, we achieved significantly enhanced upconversion luminescence in dye-sensitized core/active shell UCNPs via the doping of ytterbium ions (Yb(3+)) in the UCNP shell, which bridged the energy transfer from the dye to the UCNP core. As a result, we synergized the two most practical upconversion booster effectors (dye-sensitizing and core/shell enhancement) to amplify upconversion efficiency. We demonstrated two biomedical applications using these UCNPs. By using dye-sensitized core/active shell UCNP embedded poly(methyl methacrylate) polymer implantable systems, we successfully shifted the optogenetic neuron excitation window to a biocompatible and deep tissue penetrable 800 nm wavelength. Furthermore, UCNPs were water-solubilized with Pluronic F127 with high upconversion efficiency and can be imaged in a mouse model.Source
ACS Nano. 2016 Jan 26;10(1):1060-6. doi: 10.1021/acsnano.5b06383. Epub 2016 Jan 11. Link to article on publisher's siteDOI
10.1021/acsnano.5b06383Permanent Link to this Item
http://hdl.handle.net/20.500.14038/37887PubMed ID
26736013Notes
Co-author Kendra Takle is a doctoral student in the Neuroscience Program in the Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.
Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1021/acsnano.5b06383