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Excitatory neurons sculpt GABAergic neuronal connectivity in the C. elegans motor circuit
Authors
Barbagallo, BelindaPhilbrook, Alison
Touroutine, Denis
Banerjee, Navonil
Oliver, Devyn
Lambert, Christopher M.
Francis, Michael M.
Devyn Oliver
Student Authors
Belinda BarbagalloNavonil Banerjee
Alison Philbrook
Devyn Oliver
Academic Program
NeuroscienceDocument Type
Journal ArticlePublication Date
2017-05-15Keywords
E/I balanceGABA synapse
Neural circuit
Neural development
Developmental Biology
Neuroscience and Neurobiology
Metadata
Show full item recordAbstract
Establishing and maintaining the appropriate number of GABA synapses is key for balancing excitation and inhibition in the nervous system, though we have only a limited understanding of the mechanisms controlling GABA circuit connectivity. Here, we show that disrupting cholinergic innervation of GABAergic neurons in the C. elegans motor circuit alters GABAergic neuron synaptic connectivity. These changes are accompanied by a reduced frequency and increased amplitude of GABAergic synaptic events. Acute genetic disruption in early development-during the integration of post-embryonic born GABAergic neurons into the circuit-produces irreversible effects on GABAergic synaptic connectivity that mimic those produced by chronic manipulations. In contrast, acute genetic disruption of cholinergic signaling in the adult circuit does not reproduce these effects. Our findings reveal that GABAergic signaling is regulated by cholinergic neuronal activity, likely through distinct mechanisms in the developing and mature nervous system.Source
Development. 2017 May 15;144(10):1807-1819. doi: 10.1242/dev.141911. Epub 2017 Apr 18. Link to article on publisher's siteDOI
10.1242/dev.141911Permanent Link to this Item
http://hdl.handle.net/20.500.14038/37930PubMed ID
28420711Notes
Belinda Barbagallo, Alison Philbrook, Navonil Banerjee and Devyn Oliver are doctoral students in the Neuroscience Program in the Morningside Graduate School of Biomedical Sciences (GSBS) at UMass Medical School.
Related Resources
Link to Article in PubMedRights
© 2017. Published by The Company of Biologists Ltd. Publisher PDF posted as allowed by the publisher's license at http://www.biologists.com/user-licence-1-1/.ae974a485f413a2113503eed53cd6c53
10.1242/dev.141911