The molecular interplay between axon degeneration and regeneration
Byrne, Alexandra B.
Fournier, Alyson E.
Student AuthorsVictoria Julian Czech
UMass Chan AffiliationsGraduate School of Biomedical Sciences, Neuroscience Program
Document TypeJournal Article
dual leucine zipper kinase
nicotinamide mononucleotide adenylyltransferase (NMNAT)
Molecular and Cellular Neuroscience
MetadataShow full item record
AbstractNeurons face a series of morphological and molecular changes following trauma and in the progression of neurodegenerative disease. In neurons capable of mounting a spontaneous regenerative response, including invertebrate neurons and mammalian neurons of the peripheral nervous system (PNS), axons regenerate from the proximal side of the injury and degenerate on the distal side. Studies of Wallerian degeneration slow (Wld(S) /Ola) mice have revealed that a level of coordination between the processes of axon regeneration and degeneration occurs during successful repair. Here, we explore how shared cellular and molecular pathways that regulate both axon regeneration and degeneration coordinate the two distinct outcomes in the proximal and distal axon segments.
Dev Neurobiol. 2018 Jul 18. doi: 10.1002/dneu.22627. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/37960