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    Differential expression of neurexin genes in the mouse brain

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    Authors
    Uchigashima, Motokazu
    Cheung, Amy
    Suh, Julie
    Watanabe, Masahiko
    Futai, Kensuke
    Student Authors
    Amy Cheung
    Academic Program
    MD/PhD
    UMass Chan Affiliations
    Graduate School of Biomedical Sciences, MD/PhD Program
    Futai Lab
    Neurobiology
    Brudnick Neuropsychiatric Research Institute
    Document Type
    Journal Article
    Publication Date
    2019-02-13
    Keywords
    RRID AB_514500
    RRID AB_840257
    RRIDs
    RRID SCR_003070
    brain
    in situ hybridization
    mice
    neurexin
    synapse
    trans-synaptic adhesion
    Amino Acids, Peptides, and Proteins
    Animal Experimentation and Research
    Genetic Phenomena
    Nervous System
    Neurology
    Neuroscience and Neurobiology
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    Link to Full Text
    https://doi.org/10.1002/cne.24664
    Abstract
    Synapses, highly specialized membrane junctions between neurons, connect presynaptic neurotransmitter release sites and postsynaptic ligand-gated channels. Neurexins (Nrxns), a family of presynaptic adhesion molecules, have been characterized as major regulators of synapse development and function. Via their extracellular domains, Nrxns bind to different postsynaptic proteins, generating highly diverse functional readouts through their postsynaptic binding partners. Not surprisingly given these versatile protein interactions, mutations and deletions of Nrxn genes have been identified in patients with autism spectrum disorders, intellectual disabilities, and schizophrenia. Therefore, elucidating the expression profiles of Nrxns in the brain is of high significance. Here, using chromogenic and fluorescent in situ hybridization, we characterize the expression patterns of Nrxn isoforms throughout the brain. We found that each Nrxn isoform displays a unique expression profile in a region-, cell type-, and sensory system-specific manner. Interestingly, we also found that alphaNrxn1 and alphaNrxn2 mRNAs are expressed in non-neuronal cells, including astrocytes and oligodendrocytes. Lastly, we found diverse expression patterns of genes that encode Nrxn binding proteins, such as Neuroligins (Nlgns), Leucine-rich repeat transmembrane neuronal protein (Lrrtms) and Latrophilins (Adgrls), suggesting that Nrxn proteins can mediate numerous combinations of trans-synaptic interactions. Together, our anatomical profiling of Nrxn gene expression reflects the diverse roles of Nrxn molecules.
    Source

    J Comp Neurol. 2019 Feb 13. doi: 10.1002/cne.24664. [Epub ahead of print] Link to article on publisher's site

    DOI
    10.1002/cne.24664
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/37965
    PubMed ID
    30761534
    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1002/cne.24664
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    Morningside Graduate School of Biomedical Sciences Scholarly Publications
    Neurobiology Student Publications
    Neurobiology Faculty Publications

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