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    Newly Identified Sleep-Wake and Circadian Circuits as Potential Therapeutic Targets

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    Authors
    Venner, Anne
    Todd, William D.
    Fraigne, Jimmy
    Bowrey, Hannah
    Eban-Rothschild, Ada
    Kaur, Satvinder
    Anaclet, Christelle
    UMass Chan Affiliations
    Anaclet Lab
    NeuroNexus Institute
    Neurobiology
    Brudnick Neuropsychiatric Research Institute
    Document Type
    Journal Article
    Publication Date
    2019-02-05
    Keywords
    parafacial zone
    ventral tegmental area
    hypercapnia
    REM behavioral disorder
    aggression
    photic regulation of arousal and mood
    Neuroscience and Neurobiology
    
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    Link to Full Text
    https://doi.org/10.1093/sleep/zsz023
    Abstract
    Optogenetics and chemogenetics are powerful tools, allowing the specific activation or inhibition of targeted neuronal sub-populations. Application of these techniques to sleep and circadian research has resulted in the unveiling of several neuronal populations that are involved in sleep-wake control, and allowed a comprehensive interrogation of the circuitry through which these nodes are coordinated to orchestrate the sleep-wake cycle. In this review, we discuss six recently described sleep-wake and circadian circuits that show promise as therapeutic targets for sleep medicine. The parafacial zone (PZ) and the ventral tegmental area (VTA) are potential druggable targets for the treatment of insomnia. The brainstem circuit underlying rapid eye movement (REM) sleep behavior disorder (RBD) offers new possibilities for treating RBD and neurodegenerative synucleinopathies, while the parabrachial nucleus, as a nexus linking arousal state control and breathing, is a promising target for developing treatments for sleep apnea. Therapies that act upon the hypothalamic circuitry underlying the for circadian regulation of aggression or the photic regulation of arousal and mood (PRAM) pathway carry enormous potential for helping to reduce the socio-economic burden of neuropsychiatric and neurodegenerative disorders on society. Intriguingly, the development of chemogenetics as a therapeutic strategy is now well underway and such an approach has the capacity to lead to more focused and less invasive therapies for treating sleep-wake disorders and related comorbidities.
    Source

    Sleep. 2019 Feb 5. pii: 5306564. doi: 10.1093/sleep/zsz023. [Epub ahead of print] Link to article on publisher's site

    DOI
    10.1093/sleep/zsz023
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/37969
    PubMed ID
    30722061
    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1093/sleep/zsz023
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