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    In Situ Regulated Dopamine Transporter Trafficking: There's No Place Like Home

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    Authors
    Fagan, Rita R.
    Kearney, Patrick J.
    Melikian, Haley E.
    Student Authors
    Rita Fagan
    Patrick Kearney
    Academic Program
    Neuroscience
    UMass Chan Affiliations
    Melikian Lab
    Graduate School of Biomedical Sciences, Neuroscience Program
    Brudnick Neuropsychiatric Research Institute
    Neurobiology
    Document Type
    Journal Article
    Publication Date
    2020-03-07
    Keywords
    Dopamine transporter
    Membrane trafficking
    Striatum
    Neuroscience and Neurobiology
    
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    Link to Full Text
    https://doi.org/10.1007/s11064-020-03001-6q
    Abstract
    Dopamine (DA) is critical for motivation, reward, movement initiation, and learning. Mechanisms that control DA signaling have a profound impact on these important behaviors, and additionally play a role in DA-related neuropathologies. The presynaptic SLC6 DA transporter (DAT) limits extracellular DA levels by clearing released DA, and is potently inhibited by addictive and therapeutic psychostimulants. Decades of evidence support that the DAT is subject to acute regulation by a number of signaling pathways, and that endocytic trafficking strongly regulates DAT availability and function. DAT trafficking studies have been performed in a variety of model systems, including both in vitro and ex vivo preparations. In this review, we focus on the breadth of DAT trafficking studies, with specific attention to, and comparison of, how context may influence DAT's response to different stimuli. In particular, this overview highlights that stimulated DAT trafficking not only differs between in vitro and ex vivo environments, but also is influenced by both sex and anatomical subregions.
    Source

    Fagan RR, Kearney PJ, Melikian HE. In Situ Regulated Dopamine Transporter Trafficking: There's No Place Like Home. Neurochem Res. 2020 Mar 7. doi: 10.1007/s11064-020-03001-6. Epub ahead of print. PMID: 32146647. Link to article on publisher's site

    DOI
    10.1007/s11064-020-03001-6
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/37987
    PubMed ID
    32146647
    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1007/s11064-020-03001-6
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    Collections
    Morningside Graduate School of Biomedical Sciences Scholarly Publications
    Neurobiology Student Publications
    Neurobiology Faculty Publications

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