In Situ Regulated Dopamine Transporter Trafficking: There's No Place Like Home
Student Authors
Rita FaganPatrick Kearney
Academic Program
NeuroscienceUMass Chan Affiliations
Melikian LabGraduate School of Biomedical Sciences, Neuroscience Program
Brudnick Neuropsychiatric Research Institute
Neurobiology
Document Type
Journal ArticlePublication Date
2020-03-07
Metadata
Show full item recordAbstract
Dopamine (DA) is critical for motivation, reward, movement initiation, and learning. Mechanisms that control DA signaling have a profound impact on these important behaviors, and additionally play a role in DA-related neuropathologies. The presynaptic SLC6 DA transporter (DAT) limits extracellular DA levels by clearing released DA, and is potently inhibited by addictive and therapeutic psychostimulants. Decades of evidence support that the DAT is subject to acute regulation by a number of signaling pathways, and that endocytic trafficking strongly regulates DAT availability and function. DAT trafficking studies have been performed in a variety of model systems, including both in vitro and ex vivo preparations. In this review, we focus on the breadth of DAT trafficking studies, with specific attention to, and comparison of, how context may influence DAT's response to different stimuli. In particular, this overview highlights that stimulated DAT trafficking not only differs between in vitro and ex vivo environments, but also is influenced by both sex and anatomical subregions.Source
Fagan RR, Kearney PJ, Melikian HE. In Situ Regulated Dopamine Transporter Trafficking: There's No Place Like Home. Neurochem Res. 2020 Mar 7. doi: 10.1007/s11064-020-03001-6. Epub ahead of print. PMID: 32146647. Link to article on publisher's site
DOI
10.1007/s11064-020-03001-6Permanent Link to this Item
http://hdl.handle.net/20.500.14038/37987PubMed ID
32146647Related Resources
ae974a485f413a2113503eed53cd6c53
10.1007/s11064-020-03001-6