AuthorsFoley, Lauren E.
UMass Chan AffiliationsGraduate School of Biomedical Sciences
Document TypeJournal Article
Amino Acids, Peptides, and Proteins
Enzymes and Coenzymes
Neuroscience and Neurobiology
MetadataShow full item record
AbstractCRYPTOCHROMES (CRYs) are structurally related to ultraviolet (UV)/blue-sensitive DNA repair enzymes called photolyases but lack the ability to repair pyrimidine dimers generated by UV exposure. First identified in plants, CRYs have proven to be involved in light detection and various light-dependent processes in a broad range of organisms. In Drosophila, CRY's best understood role is the cell-autonomous synchronization of circadian clocks. However, CRY also contributes to the amplitude of circadian oscillations in a light-independent manner, controls arousal and UV avoidance, influences visual photoreception, and plays a key role in magnetic field detection. Here, we review our current understanding of the mechanisms underlying CRY's various circadian and noncircadian functions in fruit flies.
Foley LE, Emery P. Drosophila Cryptochrome: Variations in Blue. J Biol Rhythms. 2020 Feb;35(1):16-27. doi: 10.1177/0748730419878290. Epub 2019 Oct 10. PMID: 31599203; PMCID: PMC7328257. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/37991