• Login
    View Item 
    •   Home
    • UMass Chan Departments, Programs and Centers
    • Neurobiology
    • Neurobiology Faculty Publications
    • View Item
    •   Home
    • UMass Chan Departments, Programs and Centers
    • Neurobiology
    • Neurobiology Faculty Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of eScholarship@UMassChanCommunitiesPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywordsThis CollectionPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywordsProfilesView

    My Account

    LoginRegister

    Help

    AboutSubmission GuidelinesData Deposit PolicySearchingUsage StatisticsAccessibilityTerms of UseWebsite Migration FAQ

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    DLGS97/SAP97 is developmentally upregulated and is required for complex adult behaviors and synapse morphology and function

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    304.full_1_.pdf
    Size:
    17.05Mb
    Format:
    PDF
    Download
    Authors
    Mendoza-Topaz, Carolina
    Urra, Francisco
    Barria, Romina
    Albornoz, Valeria
    Ugalde, Diego
    Thomas, Ulrich
    Gundelfinger, Eckart
    Delgado, Ricardo
    Kukuljan, Manuel
    Sanxaridis, Parthena D.
    Tsunoda, Susan
    Ceriani, M. Fernanda
    Budnik, Vivian
    Sierralta, Jimena
    Show allShow less
    UMass Chan Affiliations
    Budnik Lab
    Neurobiology
    Document Type
    Journal Article
    Publication Date
    2008-01-02
    Keywords
    Animals
    Animals, Genetically Modified
    Behavior, Animal
    Circadian Rhythm
    Drosophila
    Drosophila Proteins
    Embryo, Nonmammalian
    Gene Expression Regulation, Developmental
    Green Fluorescent Proteins
    Membrane Potentials
    Microscopy, Electron, Transmission
    Motor Activity
    Mutation
    Neuromuscular Junction
    Protein Isoforms
    Sexual Behavior, Animal
    Tumor Suppressor Proteins
    Neuroscience and Neurobiology
    Show allShow less
    
    Metadata
    Show full item record
    Abstract
    The synaptic membrane-associated guanylate kinase (MAGUK) scaffolding protein family is thought to play key roles in synapse assembly and synaptic plasticity. Evidence supporting these roles in vivo is scarce, as a consequence of gene redundancy in mammals. The genome of Drosophila contains only one MAGUK gene, discs large (dlg), from which two major proteins originate: DLGA [PSD95 (postsynaptic density 95)-like] and DLGS97 [SAP97 (synapse-associated protein)-like]. These differ only by the inclusion in DLGS97 of an L27 domain, important for the formation of supramolecular assemblies. Known dlg mutations affect both forms and are lethal at larval stages attributable to tumoral overgrowth of epithelia. We generated independent null mutations for each, dlgA and dlgS97. These allowed unveiling of a shift in expression during the development of the nervous system: predominant expression of DLGA in the embryo, balanced expression of both during larval stages, and almost exclusive DLGS97 expression in the adult brain. Loss of embryonic DLGS97 does not alter the development of the nervous system. At larval stages, DLGA and DLGS97 fulfill both unique and partially redundant functions in the neuromuscular junction. Contrary to dlg and dlgA mutants, dlgS97 mutants are viable to adulthood, but they exhibit marked alterations in complex behaviors such as phototaxis, circadian activity, and courtship, whereas simpler behaviors like locomotion and odor and light perception are spared. We propose that the increased repertoire of associations of a synaptic scaffold protein given by an additional domain of protein-protein interaction underlies its ability to integrate molecular networks required for complex functions in adult synapses.
    Source
    J Neurosci. 2008 Jan 2;28(1):304-14. Link to article on publisher's site
    DOI
    10.1523/JNEUROSCI.4395-07.2008
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/38007
    PubMed ID
    18171947
    Related Resources
    Link to Article in PubMed
    Rights
    Copyright of all material published in The Journal of Neuroscience remains with the authors. The authors grant the Society for Neuroscience an exclusive license to publish their work for the first 6 months. After 6 months the work becomes available to the public to copy, distribute, or display under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.
    ae974a485f413a2113503eed53cd6c53
    10.1523/JNEUROSCI.4395-07.2008
    Scopus Count
    Collections
    Neurobiology Faculty Publications

    entitlement

    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Lamar Soutter Library, UMass Chan Medical School | 55 Lake Avenue North | Worcester, MA 01655 USA
    Quick Guide | escholarship@umassmed.edu
    Works found in eScholarship@UMassChan are protected by copyright unless otherwise indicated.
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.