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    Prolonged G(q) activity triggers fly rhodopsin endocytosis and degradation, and reduces photoreceptor sensitivity

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    Authors
    Han, Junhai
    Reddig, Keith
    Li, Hong-Sheng
    UMass Chan Affiliations
    Li Lab
    Neurobiology
    Document Type
    Journal Article
    Publication Date
    2007-12-12
    Keywords
    Animals
    Animals, Genetically Modified
    Arrestins
    Drosophila Proteins
    *Drosophila melanogaster
    Dynamins
    Endocytosis
    GTP-Binding Protein alpha Subunits, Gq-G11
    Light
    Membrane Proteins
    Phospholipase C beta
    Photoreceptor Cells, Invertebrate
    Recombinant Fusion Proteins
    Rhodopsin
    Second Messenger Systems
    Trans-Activators
    Neuroscience and Neurobiology
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    Link to Full Text
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2140116/pdf/7601929a.pdf
    Abstract
    Rapid deactivation of the Drosophila light receptor rhodopsin, through a visual arrestin Arr2 and a pathway that involves a transcription factor dCAMTA, is required for timely termination of light responses in the photoreceptor neuron. Here we report that this process is also critical for maintenance of the photoreceptor sensitivity. In both dCAMTA- and arr2-mutant flies, the endocytosis of the major rhodopsin Rh1 was dramatically increased, which was mediated by a G(q) protein that signals downstream of rhodopsin in the visual transduction pathway. Consequently, the Rh1 level was downregulated and the photoreceptor became less sensitive to light. Remarkably, the G(q)-stimulated Rh1 endocytosis does not require phospholipase C, a known effector of G(q), but depends on a tetraspanin protein. Our work has identified an arrestin-independent endocytic pathway of G protein-coupled receptor in the fly. This pathway may also function in mammals and mediate an early feedback regulation of receptor signaling.
    Source
    EMBO J. 2007 Dec 12;26(24):4966-73. Epub 2007 Nov 22. Link to article on publisher's site
    DOI
    10.1038/sj.emboj.7601929
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/38008
    PubMed ID
    18034157
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.emboj.7601929
    Scopus Count
    Collections
    Neurobiology Faculty Publications

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